外伤后难治性癫痫的高危因素分析  

Analysis of high-risk factors for traumatic intractable epilepsy

作　　者：王强[1] 杨娟 罗杰[1] 李文魁[1] 高磊 李洪波[1] 郭世刚[1] 

机构地区：[1]枣阳市第一人民医院神经外科,441200 [2]枣阳市第一人民医院药剂科,441200

出　　处：《临床神经外科杂志》2017年第5期339-341,共3页Journal of Clinical Neurosurgery

摘　　要：目的研究颅脑损伤后并发难治性癫痫(IE)的危险因素,为临床及早干预提供参考依据。方法对2010年9月~2013年9月在枣阳市第一人民医院神经外科治疗好转出院,资料完整且得到随访的682例颅脑损伤患者的临床资料进行回顾性分析。比较伤后出现IE和非IE患者的相关临床因素,对有统计学意义的相关因素进行Logistic回归分析。结果两组患者的年龄、首次入院时伤情、颅脑损伤部位、硬脑膜是否完整和手术方式比较,差异均有统计学意义(P<0.05~0.001)。Logistic回归分析显示,以上指标均是颅脑外伤后发生IE的危险因素(P<0.05~0.001)。结论重型颅脑损伤、中老年、皮层损伤、硬脑膜破损及开颅手术治疗是外伤后发生IE的高危因素。Objective To explore the high-risk factors in traumatic intractable epilepsy. Methods The clinical data of 682 patients with traumatic brain injury（TBI） discharged and followed up from September 2010 to September 2013 were analyzed retrospectively. Binary logistic regression analysis was used to screen the risk factors of traumatic intractable epilepsy. Results Serious TBI, older age ,cortical injury, dura breakage and neurosurgical treatment would increase the incidence of intractable epilepsy （ P 〈 0. 05-0. 001 ）. Condusion Serious TBI, older age, cortical injury, dura breakage and neurosurgieal treatment are high-risk factors for traumatic intractable epilepsy.

关 键 词：颅脑损伤 难治性癫痫 危险因素 

分 类 号：R742.1[医药卫生—神经病学与精神病学]