胰岛素样生长因子1及其受体在结直肠癌中的表达及其意义  

Expression of insulin-like growth factor 1 and its receptors in colorectal cancer and their significances

作　　者：琚静 韩存芝[2] 昝丽坤 李怡欣 江波[5] 

机构地区：[1]山西医科大学研究生学院,太原030001 [2]山西省肿瘤研究所病因室,太原030013 [3]山西医科大学附属肿瘤医院病理科,太原030013 [4]山西医科大学第一医院临床药学部,太原030001 [5]山西医科大学附属肿瘤医院结直肠肛门外科,太原030013

出　　处：《肿瘤研究与临床》2017年第9期593-597,共5页Cancer Research and Clinic

摘　　要：目的 探讨胰岛素样生长因子（IGF）1、IGF受体1（IGF-1R）及IGF受体2（IGF-2R）在结直肠癌中的表达及其与临床病理因素的关系.方法 应用免疫组织化学SP法检测154例结直肠癌组织、58例良性病变组织（结直肠腺瘤、息肉）及90例癌旁正常组织中IGF-1、IGF-1R及IGF-2R的表达情况.结果 IGF-1、IGF-1R在结直肠癌组织中的阳性表达率[93.5%（144/154）、70.1%（108/154）]高于良性病变组织[51.7%（30/58）、51.7%（30/58）]及癌旁正常组织[18.9%（17/90）、35.6%（32/90）]（P=0.001）;IGF-1和IGF-1R在三组间的阳性表达率逐渐降低,且两两比较差异均有统计学意义（均P〈0.05）,IGF-2R在三组之间两两比较差异均无统计学意义（均P〉0.05）.IGF-1、IGF-1R、IGF-2R在结直肠癌组织中的表达与患者性别、肿瘤部位、肿瘤大小、家族史、肿瘤浸润深度、局部淋巴结转移均无明显相关性（均P〉0.05）.IGF-1与患者的体质量指数呈正相关（r=0.169,P=0.036）.IGF-2R的表达与患者年龄呈负相关（r=-0.196,P=0.015）,与TNM分期呈正相关（r=0.227,P=0.005）.在结直肠癌组织中,IGF-1与IGF-1R的表达呈正相关（r=0.281,P=0.0001）,IGF-1与IGF-2R的表达无相关性（P〉0.05）.结论 IGF-1、IGF-1R可能促进结直肠癌的发生,IGF-2R可能与结直肠癌的进展有一定相关性.肥胖是导致结直肠癌发生的危险因素之一.Objective To investigate the expression of insulin-like growth factor 1 （IGF-1）, insulin growth factor receptor 1（IGF-1R）and insulin growth factor receptor 2（IGF-2R）in colorectal cancer, and their relationship with the relevant clinicopathological factors. Methods Immunohistochemical SP method was used to detect the expression of IGF-1,IGF-1R and IGF-2R in 154 cases of colorectal cancer tissues,58 cases of benign disease tissues （colorectal adenoma, polyps） and 90 normal tissues. Results The positive rate of IGF-1 and IGF-1R expression in colorectal cancer tissues [93.5%（144/154）, 70.1%（108/154）] was higher than that in benign diseases [51.7%（30/58）, 51.7%（30/58）] and adjacent normal tissues [18.9%（17/90）, 35.6%（32/90）] （P=0.001）. The positive expression rate of IGF-1 and IGF-1R in colorectal cancer tissue, benign disease tissue and adjacent normal tissues decreased gradually, and there was significant difference between any two groups （P〈0.05）. The positive expression rate of IGF-2R had no significant difference between any two groups （P〉0.05）. IGF-2R was significantly different between any two groups （P〈0.05）. The expression of IGF-1R and IGF-2R in colorectal cancer tissues were not significantly correlated with gender, location, tumor size, family history, depth of tumor invasion and local lymph node metastasis （all P〉0.05）.IGF-1 was positively correlated with the body mass index（r=0.169,P=0.036）.IGF-2R was negatively correlated with age （r=-0.196, P=0.015）, and positively correlated with TNM staging in patients with colorectal cancer （r=0.227, P=0.005）. The expression of IGF-1 was positively correlated with IGF-1R （r=0.281, P=0.000 1）. There was no significant correlation between IGF-1 and IGF-2R in cancer tissues （P〉0.05）. Conclusion IGF-1 and IGF-1R may promote the occurrence of colorectal cancer, and IGF-2R may be associated with the progress of colorectal cancer,and obesity is a risk factor for incidence of colorecta

关 键 词：结直肠肿瘤 胰岛素样生长因子1 受体 IGF1型 受体 IGF2型 

分 类 号：R735.34[医药卫生—肿瘤]