巨噬细胞与Wnt通路在肿瘤发生发展中的作用  

The role of macrophages and Wnt signaling in tumor initiation and progression

作　　者：刘明江 叶雨辰 秦鸿雁[2] 

机构地区：[1]第四军医大学航空航天医学系学员五营,西安710032 [2]第四军医大学基础部遗传学与发育生物学教研室,西安710032 [3]第四军医大学西京医院肝胆外科,西安710032

出　　处：《生命的化学》2017年第5期719-725,共7页Chemistry of Life

基　　金：国家自然科学基金重大研究计划培育项目(31371474);国家自然科学基金面上项目(31570878);第四军医大学博士学位论文课题资助项目(2016D07)

摘　　要：巨噬细胞作为机体固有免疫的重要成员,具有高度异质性,在肿瘤发生发展过程中的多个方面发挥重要作用。Wnt信号通路分子广泛表达于胚胎和成年个体组织,在胚胎/成体干细胞分化、发育和功能调控中发挥重要作用,而且参与多种肿瘤的发生发展过程。近年来越来越多研究表明,Wnt信号通路参与调控巨噬细胞的分化及功能。本文就巨噬细胞与Wnt信号通路对肿瘤发生发展作用的研究进展作一综述。As an important member of the innate immune system,macrophages are highly heterogeneous,playing critical roles in many aspects of tumorigenesis and tumor progression.Widely expressed in both embryonic and adult tissues,Wnt signaling molecules are of much significance in the differentiation,development and functional regulation of embryonic/adult stem cells and participate in the development of many tumors as well.In recent years,more and more studies have shown that Wnt signaling pathway is involved in the regulation of macrophage differentiation and function.This article reviews the research advances in the role of macrophages and Wnt signaling pathway in tumor initiation and progression.

关 键 词：巨噬细胞 肿瘤相关巨噬细胞 异质性 WNT信号通路 

分 类 号：R730.231[医药卫生—肿瘤]