非诺贝特的抗肿瘤作用  

Anticancer properties of fenofibrate

作　　者：沈雅婷 胡端敏[1] 

机构地区：[1]苏州大学附属第二医院消化科,215004

出　　处：《国际肿瘤学杂志》2017年第9期682-685,共4页Journal of International Oncology

基　　金：苏州市科技计划（SYS201632）

摘　　要：非诺贝特作为临床常见的降脂药，主要通过激活过氧化物酶体增殖物激活受体α（PPRAα）产生降脂作用。研究表明非诺贝特可以通过抑制肿瘤细胞增殖代谢、抑制新生血管形成、阻滞细胞周期、抑制细胞运动迁移、诱导细胞凋亡等来发挥抗肿瘤作用，且以上作用不全依赖PPRAα途径。非诺贝特不良反应小，有望辅助肿瘤临床内科治疗。Fenofibrate is a common lipidlowing drug activating peroxisome proliferatoractivated receptor alpha （PPRAα）. Recent studies have found that fenofibrate possesses anticancer properties. Its specific mechanisms include inhibiting cell metabolism and formation of new tumor vessels, arresting cell circle, weakening cell motility, and inducing cell apoptosis. Those properties are partly independent of PPRAα. Due to its low sideeffects, it′s hopefully to be used as an anticancer adjuvant drug.

关 键 词：普鲁脂芬 肿瘤 细胞凋亡 细胞周期 

分 类 号：R73-36[医药卫生—肿瘤]