雌激素受体与乳腺癌内分泌治疗耐药的相关性研究  

Relationship between estrogen receptor and the drug resistance to endocrine therapy in breast cancer

作　　者：颜宁[1] 陈迪[1] 冯得财[1] 彭伟强[1] 黄宇康[1] 吴楚成[1] 

机构地区：[1]广东省惠州市中心人民医院乳腺外科,惠州516001

出　　处：《中国肿瘤临床与康复》2017年第11期1304-1306,共3页Chinese Journal of Clinical Oncology and Rehabilitation

基　　金：惠州市科技计划项目(2016Y016)

摘　　要：目的探讨雌激素受体β(ERβ)与乳腺癌内分泌治疗耐药的相关性。方法选取2010年1月至2015年6月间广东省惠州市中心人民医院收治的行乳腺癌改良根治术且接受他莫昔芬(TAM)内分泌治疗的100例早中期绝经后乳腺癌患者。检测乳腺癌患者ERβ表达情况,计算患者无肿瘤生存时间,比较不同ERβ表达患者间临床因素和预后的差异,分析ERβ表达差异与TAM内分泌治疗耐药的关系。结果 ERβ表达与原癌基因人类表皮生长因子受体2(HER-2)的表达相关,差异有统计学意义(P<0.05),与患者年龄、肿瘤大小、淋巴结转移、化疗及放疗无关,差异无统计学意义(P>0.05)。ERβ阳性表达患者无肿瘤生存率明显低于ERβ阴性表达患者,差异有统计学意义(P<0.05)。Cox多因素分析显示,ERβ阳性表达患者中,淋巴结转移是乳腺癌内分泌治疗预后不良的独立危险因素,差异有统计学意义(P<0.05)。结论 ERβ阳性表达在乳腺癌患者内分泌治疗耐药中具有重要作用,可能是导致患者预后不佳的危险因素之一。Objective To detect the relationship between estrogen receptor beta（ ERβ） and the resistance to endocrine therapy in breast cancer. Methods One hundred postmenopausal patients with early and middle stage breast cancer who underwent modified radical mastectomy and received tamoxifen（ TAM） as endocrine therapy were selected at Huizhou Central People＇s Hospital from January 2010 to June 2015. The expression of ER was detected. Tumor-free survival time was calculated. Differences in clinical and prognostic factors were compared among patients with different expression of ERβ. The relationship between the expression of ERβ and resistance to TAM endocrine therapy was analyzed. Results The expression of ERβ was associated with human epidermal growth factor receptor 2（ HER-2）（ P〈0. 05） rather than with patient age,tumor size,lymph node metastasis,chemotherapy and radiotherapy（ P〈0. 05）. Patients with positive expression of ERβ slowed significantly lower tumor-free survival rate than patients with negative expression（ P〈0. 05）. Cox multivariate analysis showed that for the positive expression of ER beta,lymph node metastasis was an independent risk factor for the poor prognosis in breast cancer treated with endocrine therapy（ P〈0. 05）. Conclusion The positive expression of ERβ plays an important role in resistance to endocrine therapy,which may be one of the risk factors leading to the poor prognosis of patients with breast cancer.

关 键 词：乳腺肿瘤 内分泌治疗 雌激素受体Β 耐药 

分 类 号：R737.9[医药卫生—肿瘤]