微小RNAs对早期胚胎发育和着床的影响  

Effects of MicroRNAs on Early Embryonic Development and Implantation

作　　者：徐丹[1] 王玉霞[1] 杨海婷[1] 潘翠娇 

机构地区：[1]暨南大学附属第一医院生殖科,广州510630

出　　处：《国际生殖健康／计划生育杂志》2017年第6期498-502,共5页Journal of International Reproductive Health/Family Planning

基　　金：广东省科技计划项目(2016ZC0049);广州市科学研究专项项目(2060404)

摘　　要：微小RNAs(microRNAs,miRNAs)在早期胚胎发育和着床过程中发挥调控作用。miRNA的异常表达可通过引起滋养细胞过度凋亡、胎盘血管生成异常、抑制子宫内膜蜕膜化、母胎界面免疫反应等多种途径引起早期胚胎发育异常和着床失败。此外,miRNAs多态性通过抑制滋养细胞增殖及促进细胞凋亡从而引起胚胎丢失。现就miRNAs对早期胚胎发育和着床的影响进行综述。MicroRNAs（miRNAs） play a regulatory role in early embryonic development and implantation.Abnormal expression of miRNAs may result inabnormal embryonic development and implantation failure by inducing the excessive apoptosis of trophoblasts, abnormal placental angiogenesis, inhibition of endometrial decidualization and maternal-fetal interface immune response. Moreover, the polymorphism of miRNAs leads to the embryo loss by inhibiting the proliferation of trophoblast cells and promoting apoptosis. In this article, the influence of miRNAs on early embryonic development and implantation was reviewed.

关 键 词：微RNAS 胚胎发育 胚胎植入 滋养细胞 

分 类 号：R714[医药卫生—妇产科学]