降钙素原、C-反应蛋白检测在肝衰竭合并腹腔感染中的临床价值  

Clinical Value of Procalcitonin and C-Reactive Protein Detection in Liver Failure Complicated by Intra-Abdominal Infection

作　　者：李小鹏[1] 王亮[1] 饶希[1] 熊英[1] 张伦理[1] 钟渊斌[1] 

机构地区：[1]南昌大学第一附属医院感染科江西省肝脏再生医学重点实验室,南昌330006

出　　处：《南昌大学学报（医学版）》2017年第5期33-35,共3页Journal of Nanchang University：Medical Sciences

基　　金：江西省自然科学基金面上项目(20161BAB205254)

摘　　要：目的探讨肝衰竭患者血清降钙素原(PCT)、C-反应蛋白(CRP)水平对判断革兰阳性(G+)菌和革兰阴性(G-)菌所致腹腔感染的临床价值。方法将135例肝衰竭患者根据有无并发腹腔感染分为感染组(89例)和非感染组(46例)。将89例感染组患者又根据腹水培养结果分为G+组(38例)和G-组(51例)。分别测定感染组、非感染组治疗前、治疗2周后血清PCT的水平及G+组、G-组治疗前、治疗2周后血清PCT、CRP的水平。结果感染组治疗前血清PCT水平明显高于非感染组(P<0.05),感染组治疗2周后血清PCT水平较治疗前明显下降(P<0.05)。G-组治疗前血清PCT水平明显高于G+组(P<0.05),G+组、G-组治疗2周后血清CRP水平均明显低于治疗前(均P<0.05)。结论肝衰竭患者发生腹腔感染时血清PCT、CRP水平均明显升高,且革兰阴性菌组高于革兰阳性菌组,经抗感染治疗后,血清PCT、CRP水平均明显下降,监测PCT、CRP水平变化,对评估疗效和预后有重要意义。Objective To investigate the clinical value of serum procalcitonin（PCT）and C-re-active protein（CRP）in liver failure patients with intra-abdominal infection caused by Gram-posi-tive（G＋ ）and Gram-negative（G- ）bacteria.Methods A total of 135 patients with liver failure were divided into intra-abdominal infection group（n=89）and non-infection group（n=46）.Fur-thermore,patients in infection group were divided into G＋ bacteria group（n=38）and G- bacteria group（n=51）.Serum PCT and CRP levels were measured before and after treatment for 2 weeks. Results Serum PCT level in infection group was higher than that in non-infection group before treatment（P 〈0.05）.After treatment for 2 weeks,serum PCT level decreased in both infection and non-infection groups（P 〈0.05）.Serum PCT level in G- bacteria group was higher than that in G＋ bacteria group before treatment（P 〈0.05）.After treatment for 2 weeks,serum CRP level decreased in both G- bacteria and G＋ bacteria groups（P 〈0.05）.Conclusion Serum PCT and CRP levels in liver failure patients with intra-abdominal infection are higher than those in patients without intra-abdominal infection,and those in patients with G- infection are higher than those in patients with G＋ infection.Anti-infection treatment can significantly reduce serum levels of PCT and CRP.Therefore,the monitoring of changes in PCT and CRP levels is important for assessing efficacy and prognosis.

关 键 词：肝衰竭 腹腔感染 降钙素原 C-反应蛋白 临床价值 

分 类 号：R575.3[医药卫生—消化系统] R446[医药卫生—内科学]