不同分化程度前列腺癌中P21WAF、P53、P16基因表达的意义  

Significance of the Expression of P21WAF,P53,P16 in Prostate Carcinoma with Different Differentiation Degree

作　　者：席小红[1] 

机构地区：[1]郑州大学附属医院南阳医院检验科,河南省南阳市473009

出　　处：《中国全科医学》2017年第A02期121-122,共2页Chinese General Practice

摘　　要：目的研究P21WAF、P53、P16基因在不同分化程度前列腺癌中的表达情况。方法选取2015—2016年郑州大学附属医院南阳医院56例前列腺癌手术标本。采用免疫组织化学法检测P21WAF、P53、P16基因表达情况。结果高分化腺癌、中分化腺癌、低分化腺癌P21WAF、P16、P53阳性率比较,差异均有统计学意义(P<0.05);其中高分化腺癌、中分化腺癌P21WAF、P16阳性率高于低分化腺癌,P53阳性率低于低分化腺癌,差异均有统计学意义(P<0.05)。结论 P21WAF、P53、P16在前列腺癌中表达与肿瘤的分级及预后有关。Objective To study the expression of P21 WAF, P53, P16 in prostate carcinoma with different differentiation degree. Methods 56 cases of prostate cancer surgery in the Nanyang Hospital of Zhengzhou University Affiliated Hospital from 2015 to 2016 were selected. The expressions of P21 WAF,P53,P16 were examined by S-P immunohischemical technique. Results The positive rates of P21 WAF, P16 and P53 in well differentiated adenocarcinoma, moderately differentiated adenocarcinoma and poorly differentiated adenocarcinoma were significantly different（ P 〈 0. 05）; the positive rates of P21 WAF,P16 in well differentiated adenocarcinoma, moderately differentiated adenocarcinoma were higher than those in poorly differentiated adenocarcinoma,the positive rates of P53 in well differentiated adenocarcinoma,moderately differentiated adenocarcinoma was higher than that in poorly differentiated adenocarcinoma,the differences were statistically significant（ P 〈0. 05）. Conclusion The positive expressions of P21 WAF, P53, P16 are correlated with prognosis and staging in prostate carcinoma.

关 键 词：前列腺肿瘤 细胞分化 P21WAF基因 P53基因 P16基因 

分 类 号：R737.25[医药卫生—肿瘤]