化疗栓塞术联合射频消融术治疗原发性肝癌的疗效观察及对患者血清核转录因子-κB和抑癌基因p53水平的影响  

Effect of transcatheter arterial chemoembolization combined with radiofrequency ablation in the treatment of primary liver cancer and its influence on the levels of nuclear factor kappa B and p53

作　　者：卢毅 吕娇健[1] 葛宇黎[1] 倪霜玲[1] 

机构地区：[1]丽水市人民医院感染科,浙江省丽水323000

出　　处：《中国基层医药》2017年第23期3587-3590,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨化疗栓塞术联合射频消融术治疗原发性肝癌的疗效及其对核转录因子-kB和抑癌基因p53水平的影响.方法 选取原发性肝癌患者90例,采用随机数字表法分为对照组（n=45）和观察组（n=45）.对照组采用化疗栓塞术治疗,观察组联合射频消融术治疗,连续治疗6个月;采用免疫组织化学法测定两组治疗后核转录因子-kB及p53表达情况,比较两组临床疗效及对核转录因子-kB及p53表达的影响.结果 观察组治疗后6个月卡氏评分（84.32±12.31）分,高于对照组的（64.32 ±11.24）分（t=21.295,P＜ 0.05）;观察组治疗6个月AFP水平（121.23±21.43）μg/L,低于对照组的（189.44±36.42）μg/L（t=19.853,P＜0.05）;观察组治疗后核转录因子-kB及p53阳性表达率分别为24.44％和20.00％,低于对照组的40.00％和33.33％（x^2=6.597、5.784,均P＜0.05）;观察组治疗后复发率15.56％,低于对照组28.89％（x^2 =6.126,P＜0.05）;观察组治疗后6个月生存率、12个月生存率分别为86.67％和82.22％,高于对照组的75.56％和64.44％（x^2=4.927、7.192,均P＜0.05）.结论 原发性肝癌患者在化疗栓塞术基础上联合射频消融术治疗效果理想,值得推广应用.Objective To investigate the effect of transcatheter arterial chemoembolization combined with radiofrequency ablation in the treatment of primary hepatocellular carcinoma （HCC） and its influence on the levels of nuclear factor kappa B （NF-B） and p53.Methods 90 patients with primary HCC were selected,and they were randomly divided into control group （n =45） and observation group （n =45） according to the digital table.The control group received chemoembolization treatment,the observation group was given combined radiofrequency ablation treatment.The patients were continuously treated for 6 months.Immunohistochemical assay was used to detect the expression of NF-B and p53 in two groups.The clinical curative effect and influence on the expression of NF-B and p53 were compared between the two groups.Results After 6 months of treatment,the Karnofsky score of the observation group was （84.32 ± 12.31）points,which was higher than （64.32 ± 11.24） points of the control group （t =21.295,P 〈 0.05）.After treatment for 6 months,the AFP level of the observation group was （121.23 ± 1.43） μg/L,which was lower than （189.44 ± 36.42） μg/L of the control group （t =19.853,P 〈 0.05）.After treatment,the positive expression rates of NF-B and p53 of the observation group were 24.44% and 20.00%,respectively,which were lower than 40% and 33.33 % of the control group （x^2 =6.597,5.784,all P 〈 0.05）.The recurrence rate of the observation group was 15.56%,which was lower than 28.89% of the control group （x^2 =6.126,P 〈 0.05）.The 6-month and 12-month survival rates of the observation group were 86.67% and 82.22%,respectively,which were higher than 75.56% and 64.44% of the control group （x^2 =4.927,7.192%,all P〈0.05）.Conclusion The effect of radiofrequency ablation combined with radiofrequency ablation for patients with primary liver cancer is satisfactory,which is worthy of popularization and application.

关 键 词：化疗栓塞 治疗性 导管消融术 肝肿瘤 核转录因子-ΚB 基因 N3 

分 类 号：R735.7[医药卫生—肿瘤]