β-葡萄糖醛酸苷酶的研究进展  

Research Progress in β-Glucuronidase

作　　者：黄希希 刘亚妮[1] 师少军[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院药剂科,武汉430022

出　　处：《中国药师》2017年第10期1834-1838,共5页China Pharmacist

基　　金：国家自然科学基金面上项目(编号:81273591);国家自然科学基金青年项目(编号:81503161);中央高校基本科研业务费专项资金(编号:2014YGYL003;2016YXZD050)

摘　　要：目的:综述β-葡萄糖醛酸苷酶结构、性质及其生物学功能研究进展。方法:查阅近年来国内外β-葡萄糖醛酸苷酶的相关文献报道,并进行归纳,分析,总结。结果:β-葡萄糖醛酸苷酶晶体结构由三个不同的结构域组成,其基因突变中最常见的为错义突变,会造成相应酶活性改变,从而引发黏多糖贮积症Ⅶ型等系列病变,对其在抗体导向酶解前体药疗法、酶替代疗法等领域的研究也在不断深入。结论:β-葡萄糖醛酸苷酶作为人体重要酸性水解酶,可发生多种基因突变,其在医药领域及疾病诊断等方面发挥了重要的作用,已越来越成为研究的热点。Objective：To summarize the structure, properties and biological functions ofβ-glucuronidase. Methods：By referring to the relevant literatures at home and abroad onβ-glucuronidase in recent years, this paper induced, analyzed and drew conclusions. Results：The crystal structure of humanβ-glucuronidase is comprised of three distinct structural domains. The most common mutation of β-glucuronidase is missense mutation, which results in the change of enzyme activity, and then induces a series of pathological chan-ges like MPSⅦ. The researches on β-glucuronidase used in antibody-directed enzyme prodrug drug therapy and enzyme replacement therapy are becoming deeper and deeper. Conclusion：β-Glucuronidase as an important acid hydrolytic enzyme in human has a variety of genetic mutations, and plays an important role in the fields of medicine and disease diagnosis, which has become one of research hotspots.

关 键 词：Β-葡萄糖醛酸苷酶 晶体结构 基因突变 功能 

分 类 号：R966[医药卫生—药理学]