鱼油联合维生素B1干预青春期少女原发性痛经的疗效  

Effect of fish oil and vitamin B1 on primary dysmenorrhea in adolescent girls

作　　者：梁结玲 和秀魁[2] 齐一鸣[2] 袁晓兰[2] 邹月华 梁萍 全朝兰 

机构地区：[1]广州市番禺区化龙医院,广东广州511434 [2]广东省妇幼保健院,广东广州511400

出　　处：《广州医科大学学报》2017年第1期59-62,共4页Academic Journal of Guangzhou Medical University

摘　　要：目的:观察维生素B1联合鱼油治疗方案对于少女原发性痛经(primary dysmenorrhea,PD)持续时间及严重程度的影响。方法:对332例青少年PD患者进行单盲随机临床实验,分为安慰剂组,维生素组,鱼油组及联合组,每组83人。分别以维生素B1 50 mg/d、鱼油胶囊500 mg/d为一个单位剂量,嘱患者于月经周期开始时用药,持续2个月。以复诊或电话等形式跟踪随访治疗期间患者痛经的持续时间,疼痛强度等。结果:治疗6月后,较之安慰剂组,维生素组、鱼油组及联合组患者疼痛的持续时间均明显缩短,其中联合组及鱼油组疗效优于维生素组(P<0.05);同时,三个实验组疼痛强度也均较安慰剂组减轻,以联合组疼痛积分降低程度最为显著(P<0.05)。用药6月后,实验组所有患者痛经的持续时间及疼痛强度积分均明显低于用药3月及治疗前,疗效与治疗时间有正相关关系。结论:维生素B1和鱼油均可有效控制PD症状,联合使用可达最大疗效。疼痛缓解程度与治疗时间有正相关关系,推荐用于青春期女生PD的长期管理。Objective：To determine the effect of vitamin B1 and fish oil on the duration and severity of primary dysmenorrhea （PD） in adolescent girls. Methods： A total of 332 adolescents with PD were included in a single-blind randomized clinical trial, and were divided into the placebo group, vitamin group, fish oil group and combined group, respectively （n = 83 each）. Vitamin B1 50mg/d and fish oil capsules 500 mg/d were considered as a unit dose, respectively. Patients were required to start medication at the beginning of the menstrual cycle and continued for 2 consecutive months. The duration and pain intensity of PD during the treatment were followed up by return visit or telephone. Results ： At 6m after the treatment, the duration of pain was significantly shorter in the vitamin group, fish oil group and combined group compared with that in the placebo group, and the effect in the combined group and fish oil group was better than that in the vitamin group, respectively （P〈0.05）. At the same time, the pain intensity in the three study groups was reduced compared with that in the placebo group, and reduce degree of the pain score was the most significant in the combined group （P〈0.05）. At 6m after the treatment, the duration of pain and pain intensity in all patients of the study group were significantly lower than those at 3m after the treatment and at baseline. There was a positive correlation between the effect and the treatment time. Conclusion： Vitamin B1 and fish oil can effectively control the symptoms of PD, and the combined use shows the maximum effect. There is a positive correlation between the pain relief and treatment time. The therapy is recommended for long-term management of PD in adolescent girls.

关 键 词：原发性痛经 维生素B1 鱼油 青春期 

分 类 号：S963[农业科学—水产养殖]