1,2,4-噻二唑的合成及其在药物化学中的应用  

Synthesis of 1,2,4-thiadiazoles and its applications in medicinal chemistry

作　　者：柴岭[1] 夏强强 袁江培 边启龙 詹宇鹏 徐元清[1] 徐浩[1] 陈威[1] 

机构地区：[1]河南大学化学化工学院,河南开封475004

出　　处：《化学研究》2017年第6期671-685,共15页Chemical Research

基　　金：河南省教育厅科学技术研究重点项目(15A150041);河南大学科研基金项目(2013YBZR008;ZZJJ20140007)

摘　　要：1,2,4-噻二唑是一类重要的杂环化合物.独特的生物和生理活性使其在药物化学领域有着非常广泛的应用.从简单底物出发,该类化合物的合成方法被不断报道.其中,碘催化、光催化等合成方法以原料易得、简单高效、绿色无污染等优势,已经广泛地被应用于1,2,4-噻二唑的合成.本文对1,2,4-噻二唑的合成方法以及在药物化学上的应用做了简要介绍.1,2,4-Thiadiazoles are important heterocyclic compounds which have significant applications in the field of medicinal chemistry.The synthetic methods for these compounds have been reported constantly.Among them,iodine catalysis and photocatalysis have been widely used in the synthesis of 1,2,4-thiadiazoles because of the advantages including easy availability of starting materials,high efficiency,and free of pollution.In this paper,the synthetic methods of 1,2,4-thiadiazoles reported in recent years and their applications in medicinal chemistry are briefly introduced.

关 键 词：1 2 4-噻二唑 杂环 合成 药物化学 

分 类 号：O621.3[理学—有机化学]