牙龈卟啉单胞菌调控细胞自噬的分子机制研究进展  

Research advances on the molecular mechanism of autophagy regulated by Porphyromonas gingivalis

作　　者：赵妍[1] 于阳 寇育荣[1,2] Zhao Yan;Yu Yang;Kou Yurong(Dept. of Periodontics, School of Stomatology, China Medical University, Shenyang 110002, China;Dept. of Oral Biology, School of Stomatology, China Medical University, Shenyang 110002, China)

机构地区：[1]中国医科大学附属口腔医院牙周科,沈阳110002 [2]中国医科大学附属口腔医院口腔生物学教研室,沈阳110002

出　　处：《华西口腔医学杂志》2017年第6期654-658,共5页West China Journal of Stomatology

基　　金：国家自然科学基金(81300886)~~

摘　　要：细胞自噬是细胞内一种保守的降解代谢途径,是宿主防御细菌感染的关键步骤。牙龈卟啉单胞菌(P.gingivalis)作为一种牙周致病菌,能够利用其引发的细胞自噬实现其在宿主细胞内的生存和增殖,从而逃避宿主的免疫监视。本文就P.gingivalis内化并调控各种宿主细胞发生自噬的分子机制作一综述,从而深入探讨P.gingivalis的致病作用,并拓展P.gingivalis与全身疾病关系的研究思路。Autophagy is an intracellular conservative degradation pathway. This event has been considered as a key step in host defense against bacterial infection. However, Porphyromonas gingivalis, as one of the evidence-sufficient periodontal pathogens, can utilize self-induced autophagy to achieve persistent intracellular survival and proliferation, which enable this organism to escape from host immune surveillance. This review focuses on molecular mechanism ofP. gingivalis internalization and autophagy to illuminate its pathogenesis and to fia＇ther explore the relationship between P. gingivalis and systemic diseases.

关 键 词：牙龈卟啉单胞菌 细胞自噬 血管内皮细胞 牙龈上皮细胞 

分 类 号：R781.4[医药卫生—口腔医学]