锰卟啉Mn(Ⅲ)TMPyP在缺血再灌注损伤中的作用  

The Role of Mn(Ⅲ) TMPyP in Ischemia/Reperfusion Injury

作　　者：薛帅[1] 兰佳男[1] 胡前超 曾宪鹏[1] 方泽鸿 熊艳[1] 王彦峰[1] 叶啟发[1,2] XUE Shuai;LAN Jianan;HU Qianchao;ZENG Xianpeng;FANG Zehong;XIONG Yan;WANG Yanfeng;YE Qifa(Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, ＆ Hubei Key Laboratory of Medical Technology on Transplantation,Wuhan 430071 , China;The 3rd Xiangya Hospital of Central South University ＆ Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha 410013, China)

机构地区：[1]武汉大学中南医院/武汉大学肝胆疾病研究院/武汉大学移植医学中心/移植医学技术湖北省重点实验室,湖北武汉430071 [2]中南大学湘雅三医院/卫生部移植医学工程技术研究中心,湖南长沙410013

出　　处：《武汉大学学报（医学版）》2017年第6期890-895,共6页Medical Journal of Wuhan University

基　　金：国家自然科学基金-新疆联合项目(编号:U1403222)

摘　　要：由缺血再灌注(IR)引起的肝肾损伤的病因与许多介质有关,包括氧化产物、细胞因子和活性氧(ROS)。其中ROS在缺血再灌注损伤(IRI)的过程中起着至关重要的作用,参与许多病理过程如氧化应激、细胞凋亡等过程。锰(Ⅲ)-四(4-N-甲基吡啶基)卟啉(Mn(Ⅲ)TMPyP)作为超氧化物歧化酶(SOD)和过氧化氢酶(CAT)模拟物具有减轻IRI的潜力。本文就Mn(Ⅲ)TMPyP在缺血再灌注方面的研究作一综述。The etiology of renal and hepatic injury due to ischemia-reperfusion （IR） is complexed with many mediators, including oxidant production, cytokines, and reactive oxygen species （ROS）. ROS play an important role in the process of ischemia-reperfusion injury（IRI）, and are involved in many pathological processes such as oxidative stress and apoptosis. Manganese （ Ⅲ ） tetrakis （1-methyl-4-pyridyl） porphyrin pentachloride （MnTmPyP）,acted as a mimics of superoxide dis mutase and catalase, has potential to reduce IRI. Here, we will briefly review the effect of MnT mPyP in the mechanisms of anti-IR injury.

关 键 词：活性氧 锰卟啉 缺血再灌注 

分 类 号：R364.1[医药卫生—病理学]