乙型肝炎病毒前S2基因变异与肝病发病机制的研究进展  

Pre-S2 Gene Mutant Research Progress in Liver Diseases Associated with Hepatitis B Virus

作　　者：李志军[1] 舒涛[1] 司晶[1] 徐哲[1] 郑志[1] 张亮[1] 黄伟[1] 叶少军[1] 王彦峰[1] 叶啟发[1,2] LI Zhijun;SHU Tao;SI Jing;XU Zhe;ZHENG Zhi;ZHANG Liang;HUANG Wei;YE Shaojun;WANG Yanfeng;YE Qifa(Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan University, ＆ Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan 430071 , China;The 3rd Xiangya Hospital of Central South University, ＆ Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha 410013, China)

机构地区：[1]武汉大学中南医院/武汉大学肝胆疾病研究院/武汉大学移植医学中心/移植医学技术湖北省重点实验室,湖北武汉430071 [2]中南大学湘雅三医院/卫生部移植医学工程技术研究中心,湖南长沙410013

出　　处：《武汉大学学报（医学版）》2017年第6期1019-1022,共4页Medical Journal of Wuhan University

摘　　要：乙肝病毒感染已被认为是导致许多肝病发病的主要原因。但其致病机制复杂,目前为止尚未完全阐明。近年来,许多文献报道乙肝病毒Pre-S2的基因变异是导致乙肝相关性疾病发病的重要因素之一。本文就PreS2基因变异导致相关肝病发病的最新研究进展进行综述。Hepatitis B virus （HBV） infection can result in many liver diseases. The underlying mechanisms are very complicated and have not clearly stated. Recently, many articles reported the Pre-S2 gene mu- tant of HBV were associated with occurrence of these liver diseases. In this article, we reviewed the recent progress of mechanisms leading to liver diseases linking with Pre-S2 gene mutant.

关 键 词：Pre-S变异 乙肝病毒感染 肝病 

分 类 号：R575[医药卫生—消化系统]