血清PCT与炎症指标检测对肝硬化患者细菌感染的诊断价值分析  

Diagnosis effect of serum PCT and inflammatory biomarkers detection for cirrhosis patients with bacterial infections

作　　者：张艳梅[1] 范晶华[1] 段志文[1] 范蕊璿 李武[1] 

机构地区：[1]昆明医科大学第一附属医院感染内科,云南昆明650032

出　　处：《中华医院感染学杂志》2017年第21期4833-4836,共4页Chinese Journal of Nosocomiology

基　　金：云南省感染性疾病临床重点专科建设基金资助项目(2100201);云南省科技厅-昆明医科大学联合专项基金资助项目(2015FB034)

摘　　要：目的探讨血清降钙素原对肝硬化患者继发细菌感染的诊断价值。方法选取医院2011年1月-2016年8月收治的68例肝硬化患者的临床资料进行回顾性分析,根据患者是否合并细菌感染分为感染组23例和非感染组45例,对两组患者治疗前的血清降钙素原及其相关炎症指标进行比较分析。结果感染组患者血清PCT、hs-CRP、WBC以及N%水平均较非感染组患者明显增高,差异有统计学意义(P<0.05);感染组不同感染类型患者的PCT、hs-CRP、WBC以及N%水平比较,差异无统计学意义;PCT和N%对诊断差异具有统计学意义(P<0.05),23例患者共分离病原菌23株,以革兰阴性菌15株为主,占65.22%。结论肝硬化合并细菌感染早期血液检测可表现出明显的PCT水平升高,而PCT联合N%可作为判断肝硬化合并细菌感染的血液指标。OBJECTIVE To investigate the diagnosis effect of serum PCT and inflammatory biomarkers detection for cirrhosis patients with bacterial infections.METHODS The clinical data of 68 patients with cirrhosis in our hospital from Jan.2011 to Aug.2016 were retrospectively analyzed,and were divided into infection group（n=23）and non-infection group（n=45）according to whether patients combined with bacteria infections.The serum PCT and inflammatory biomarkers detection before treatment of the two groups were compared and analyzed.RESULTS The levels of serum PCT,hs-CRP,WBC and N % of patients in infection group were significantly higher than those in non-infection groups（P〈0.05）.There was no significantly difference in the levels of PCT,hs-CRP,WBC and N% of patients with different kinds of infections in infection group.The diagnosis differences of PCT and N% were significant（P〈0.05）.Totally 23 strains of pathogenic bacteria were isolated in 23 patients,which were mainly15 strains of gram-negative bacteria,accounting for 65.22%.CONCLUSION The early blood tests of hepatocirrhosis with bacterial infections can show obvious higher PCT level,and the combination of PCT and N % can be used as indicators for judgment of cirrhosis with bacterial infections.

关 键 词：肝硬化 降钙素原 细菌感染 

分 类 号：R575.2[医药卫生—消化系统]