肠内营养混悬液对结直肠癌患者术后感染及免疫功能的影响研究  

Influence of enteral nutrition suspension on postoperative infections and immune function of colorectal cancer patients

作　　者：吕保良 刘新江[2] 潘玲[3] 黄贺梅[1] 张雪灵[3] 

机构地区：[1]郑州铁路职业技术学院医学技术系,河南郑州451460 [2]郑州大学第二附属医院普外科,河南郑州450000 [3]郑州铁路职业技术学院护理学院,河南郑州451460

出　　处：《中华医院感染学杂志》2017年第21期4953-4956,共4页Chinese Journal of Nosocomiology

摘　　要：目的分析肠内营养混悬液改善结直肠癌手术患者术后免疫功能及降低术后感染的效果,以期为降低患者结直肠癌术后感染率提供参考。方法选择2015年2月-2016年3月医院收治的结直肠癌手术患者86例作为研究对象,按照随机数字表法分为对照组和试验组,每组43例,对照组患者术后采用常规治疗及护理,试验组患者在对照组的基础上加用肠内营养混悬液,比较两组患者术前、术后一个月免疫球蛋白IgG、IgA、IgM及T淋巴细胞CD_3^+、CD_4^+、CD_8^+、CD_4^+/CD_8^+变化情况,比较两组患者术后并发症、术后一个月内感染率及病原菌构成。结果试验组患者术后感染率为9.30%,明显低于对照组的19.60%,两组比较差异有统计学意义(P<0.05);对照组患者术后IgG、IgA、IgM、CD_3^+、CD_4^+、CD_4^+/CD_8^+较术前均明显降低(P<0.05),CD_8^+较术前明显升高(P<0.05),试验组患者以上指标较术前有所降低,但差异无统计学意义,试验组患者术后IgG、IgA、IgM、CD_3^+、CD_4^+、CD_4^+/CD_8^+高于对照组患者,CD_8^+低于对照组患者,两组比较差异有统计学意义(P<0.05);试验组并发症率为16.28%明显低于对照组的27.91%,两组比较差异有统计学意义(P<0.05)。结论结直肠癌患者术后予以肠内营养混悬液,可有效保护患者免疫功能,降低患者术后感染率,具有较高的临床应用价值。OBJECTIVE To observe the effect of enteral nutrition suspension on improvement of postoperative immune function and reduction of incidence of postoperative infections in patients with colorectal cancer so as to reduce the incidence of postoperative infections in the colorectal cancer patients.METHODS A total of 86 patients with colorectal cancer who were treated in hospitals from Feb 2015 to Mar 2016 were recruited as the study objects and randomly divided into the control group and the observation group,with 43 cases in each group.The control group was treated with postoperative conventional treatment and nursing,while the observation group was given additional enteral nutrition suspension on the basis of the treatment of the control group.The levels of immunoglobins IgG,IgA and IgM as well as T lymphocytes CD3^＋,CD4^＋,CD8^＋and CD4^＋/CD8^＋were compared between the two groups of patients before the surgery and after the surgery for one month.The incidence of postoperative complications,infection rate within one month after surgery and constituent ratios of pathogens were compared between the two groups of patients.RESULTS The incidence of postoperative infection of the observation group was9.30%,significantly lower than 19.60% of the control group（P〈0.05）.The levels of IgG,IgA,IgM,CD3^＋,CD4^＋and CD4^＋/CD8^＋of the control group were significantly lower after the surgery than before the surgery（P〈0.05）,the CD8^＋level of the control group was significantly higher after the surgery than before the surgery;the levels of the above indexes of the observation group were lower after the surgery than before the surgery,however,there was no significant difference.The levels of IgG,IgA,IgM,CD3^＋,CD4^＋and CD4^＋/CD8^＋of the observation group were significantly higher than those of the control group after the surgery,the CD8^＋level of the observation group was lower than that of the control group（P〈0.05）.The incidence of complications of the observation group was 16.28%,significan

关 键 词：结直肠癌手术 肠内营养混悬液 术后感染 免疫功能 影响研究 

分 类 号：R735.3[医药卫生—肿瘤]