苏州地区门诊男性患者高危型人乳头瘤病毒基因型分析  

Analysis on high risk human papillomavirus genotypes among male outpatients in Suzhou area

作　　者：王建[1] 李文静[1] 徐红星[1] 吴冬生[1] 陈昭华[1] 

机构地区：[1]南京医科大学附属苏州市立医院本部检验科,江苏苏州215168

出　　处：《国际检验医学杂志》2017年第22期3085-3087,共3页International Journal of Laboratory Medicine

基　　金：苏州市科技计划指导性项目(SYSD2016112)

摘　　要：目的了解苏州地区门诊男性患者高危型人乳头瘤病毒(HR-HPV)的感染状况、基因型分布,以及与疾病的相关性。方法运用多重聚合酶链式反应和流式荧光杂交技术对1 432例门诊男性患者进行HR-HPV分型检测。结果 HR-HPV总感染率为25.63%,单一感染、双重感染和多重感染分别占72.20%、21.25%和0.65%,不同年龄段人群HR-HPV感染率比较,差异无统计学意义(χ~2=1.912,P=0.861)。位于前5位的HR-HPV亚型分别为HPV-16、HPV-52、HPV-58、HPV-18及HPV-59,HPV-16、HPV-52、HPV-58感染最常见于<20岁、>60岁及<20岁人群,与HR-HPV相关的前3位疾病为病毒疣、尿道炎及龟头炎。结论 HPV-16是本地区男性患者最常见的HR-HPV感染型别,其次是HPV-52、HPV-58,HR-HPV感染具有一定年龄特异性,与男性病毒疣、尿道炎及龟头炎等疾病有关。Objective To understand the infection status,genotype distribution of high risk human papillomavirus（HR-HPV）infection and its relation with diseases among male outpatients in Suzhou area.Methods The HR-HPV DNA genotyping detection in 1 432 male outpatients was performed by using multiple polymerase chain reaction and flow cytometry fluorescence hybridization technique.Results The total infection rate of HR-HPV was 25.6%（367/1 432）,single infection,double infection and multiple infection accounted for 72.20%,21.25% and 0.65% respectively.The HR-HPV infection rate had no statistical difference among different age groups（χ~2=1.912,P=0.861）.The top five places of HR-HPV subtypes were HPV-16,HPV-52,HPV-58,HPV-18 and HPV-59.HPV-16,HPV-52,HPV-58 infections were most common among the age groups of20 years old,60 years old and 20 years old,and the top 3 diseases related to HR-HPV were verruca,urethritis and balanitis.Conclusion HPV-16 is the most common HR-HPV infection type in male outpatients,followed by HPV-52 and-58.The HR-HPV infection has a certain age specificity and is related to male verruca,urethritis and balanitis.

关 键 词：男性 人乳头瘤病毒 高危型 基因型 

分 类 号：R737.33[医药卫生—肿瘤]