卒中后认知功能障碍研究新进展  

The Research Progress of Post-stroke Cognitive Impairment

作　　者：左丽君[1] 廖晓凌[1,2,3] 李子孝 杨明[1] 张巍 王拥军[1,2,3] 

机构地区：[1]首都医科大学附属北京天坛医院神经病学中心,北京100050 [2]首都医科大学附属北京天坛医院血管神经病学科 [3]国家神经系统疾病临床医学研究中心 [4]首都医科大学附属北京天坛医院临床试验和临床研究中心 [5]首都医科大学附属北京天坛医院老年病科 [6]教育部神经变性病重点实验室 [7]北京脑重大疾病研究院帕金森病研究所 [8]帕金森病研究北京市重点实验室

出　　处：《中国卒中杂志》2017年第10期962-967,共6页Chinese Journal of Stroke

摘　　要：卒中和痴呆的关系是目前研究的热点。卒中能够增加血管性认知障碍的发生风险,加速已经存在的认知功能障碍。卒中发生和认知障碍出现之间,有一段时间间隔,而这个时间间隔通常是实施干预治疗,预防认知障碍发生及进展的最佳时机。卒中可以同时激活神经血管单元的神经变性过程和血管损伤过程,从而加速认知障碍发生。本文主要阐述了卒中后认知功能障碍的发生率、病理生理机制、生物学标志物以及影像学特征、神经心理学评估方面的相关研究进展,为卒中后认知障碍的干预治疗提供思路。The relationship between stroke and dementia was a hot research topic area. Stroke could facilitate the onset of vascular dementia and aggravate pre-existing cognitive impairment. There was often a delay in the development of cognitive impairment after a stroke. This delay could be considered as the best therapeutic time window allowing interventions to preserve cognitive decline following stroke. Both neurodegenerative and vascular mechanisms were activated within the neurovascular unit and result in disease process. This review focused on the prevalence of cognitive impairment following stroke, physiopathologic mechanisms, biomarkers, imaging features and neuropsychological assessment, so as to provide new ideas for intervention treatments of post-stroke cognitive impairment.

关 键 词：卒中后认知障碍 预测因子 治疗 

分 类 号：R749.13[医药卫生—神经病学与精神病学]