长链非编码RNA与乳腺癌耐药研究  

Study on long non-coding RNA and breast cancer drug resistance

作　　者：王月月 杨清玲[2] 陈昌杰[2] 

机构地区：[1]蚌埠医学院临床检验诊断学实验中心,安徽蚌埠233000 [2]蚌埠医学院生物化学与分子生物学教研室,安徽蚌埠233000

出　　处：《分子诊断与治疗杂志》2017年第6期426-429,436,共5页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省教育厅自然科学重大项目(KJ2015ZD29;KJ2016SD37);安徽省自然科学基金(1508085MH159);安徽省高校学科(专业)拔尖人才学术资助重点项目(gxbj ZD2016069);安徽省蚌埠市科技计划项目(20150309)

摘　　要：长链非编码RNA(long non-coding RNA,lnc RNA)是一类转录本长度超过200个核苷酸功能性的RNA分子,本身不具有编码蛋白质的能力,在表观遗传学水平、转录水平、转录后水平上发挥重要的调控作用。以往研究者们对lnc RNA与肿瘤发生发展的关系进行了大量的研究。目前,学者们聚焦于lnc RNA与肿瘤耐药机制的研究,本文结合近几年国内外最新报道,对lnc RNA诱导乳腺癌耐药机制进行汇总,旨在为乳腺癌治疗寻找新的靶标和诊疗思路。Long non-coding RNA（lncRNA） is a class of functional RNA molecules with a length of more than 200 nucleotides, which does not have the ability to encode proteins. Inc RNA plays an important role in the regulation of epigenetic, transcriptional and post transcriptional levels. Previously, researches have investigated the relationship between lnc RNA and tumorigenesis. Recently, most of studies focus on the mechanisms of lnc RNA and tumor resistance. In this review, the mechanisms of lnc RNA inducing breast cancer resistance were summarized and discussed, in order to find a new target or strategy for the diagnosis and treatment of breast cancer.

关 键 词：长链非编码RNA 乳腺癌 耐药 

分 类 号：R737.9[医药卫生—肿瘤]