水通道蛋白1在人角膜内皮细胞的表达  

Expression of water channel protein 1 in human corneal endothelium

作　　者：徐春玲[1] 宋跃[1] 吴荒[1] 李晓华[1] 赵东卿[2] 赵学俭[3] 

机构地区：[1]吉林大学二院眼科,长春市130041 [2]河南省眼科研究所,450003 [3]吉林大学病理生理学教研室,130021

出　　处：《眼科新进展》2002年第4期248-250,共3页Recent Advances in Ophthalmology

摘　　要：目的　研究水通道蛋白 1(water channel protein1,AQP1)抗体在人角膜中的表达及水转运机制。方法　运用免疫组织化学法测定人角膜中 AQP1的表达。结果　在角膜内皮细胞和基质细胞中有 AQP1的表达 ,而角膜上皮细胞不表达 AQP1。结论　本实验证实了 AQP1在角膜内皮的表达 。Objective To study the antibody of water channe protein 1 (AQP1) expression in the human cornea and investigate the mechanism of water transport through the cornea.Methods Immunohistochemical technique was used to measure the expression of (AQP1) in the human cornea.Results AQP1 was expressed in corneal endothelial cells and keratocytes cells , but no expression in corneal epithelium cells. Conclusion Results showed that AQP1 existed in the corneal endothelium. This study provides a molecular biological basis to study the molecular mechanism of corneal water transport and corneal edema.

关 键 词：水通道蛋白 水通道蛋白1抗体 角膜内皮细胞 

分 类 号：R77[医药卫生—眼科]