中性条件脱保护合成2,6-二氯嘌呤核苷研究  

Synthesis of 2,6-Dichloroadenosine in Neural Conditions

作　　者：申艳红[1] 李保利[1] 王云龙 

机构地区：[1]安阳工学院化学与环境工程学院,河南安阳455000

出　　处：《安阳工学院学报》2017年第6期42-45,共4页Journal of Anyang Institute of Technology

摘　　要：以2,6-二氯嘌呤和四乙酰核糖为原料,经缩合反应制备中间体2,6-二氯嘌呤-2',3',5'-三乙酰基核苷,再脱乙酰保护基合成2,6-二氯嘌呤核苷。主要研究了在中性条件下,以二丁基氧化锡为催化剂脱除乙酰基的方法,该反应具有条件温和,易操作,后处理简单的优点。The starting material 2,6-dichloropurine was condensed with 1,2,3,5-tetraacetylribofuranose to form 2＇,3＇,5＇-triaeetyl-2,6-diehloroadenosine, which was deprotected to give the target product 2,6-diehloro- adenosine as a white crystalline powder. The deaeetylation method in neutral condition using dibutylt in oxide as catalyst was invesgated.Compared to others, this method has the advantages of mild conditions, easy operating, and simple workup procedure. Key words：

关 键 词：2 6-二氯嘌呤核苷 二丁基氧化锡 2 6-二氯嘌呤 四乙酰核糖 脱酰基 

分 类 号：O626.41[理学—有机化学]