中药药对配伍机制的现代研究  

Modern research on compatibility mechanism of Chinese materia medica pair

作　　者：宋佳 高晓霞[1] 田俊生[1] 秦雪梅[1] 杜冠华[1,3] 周玉枝[1] 

机构地区：[1]山西大学中医药现代研究中心,山西太原030006 [2]山西大学化学化工学院,山西太原030006 [3]中国医学科学院北京协和医学院药物研究所,北京100050

出　　处：《中草药》2017年第21期4367-4374,共8页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金面上项目(81673572);山西省应用基础研究项目(201601D021164);山西省高校科技创新项目(2016120)

摘　　要：药对作为中药配伍的基本形式,是沟通单味药与复方的重要桥梁,研究药对的配伍机制对揭示复方配伍的科学内涵具有重要意义。目前,许多研究者从药对配伍前后的化学成分、药动学及药理作用差异着手对药对配伍机制展开研究。通过查阅文献,归纳总结药对配伍机制的研究现状,并提出展望,以期为药对及复方配伍机制的进一步深入研究及以药对为基础的中药新药开发奠定基础。As the basic form of Chinese materia medica（CMM） prescriptions,herb pair established a bridge linking single herb and CMM formula.Studying the compatibility mechanism of herb pair has important significance for revealing the compatibility mechanism of CMM formula.At present,many researchers studied the changes of the material basis,pharmacokinetics,and pharmacological effects after herb pair combined as the breakthrough point to explore compatibility mechanism of the herbal pair.In this paper,the research status were summarized and put forward prospects of the compatibility mechanism of the herbal pair and the foundation for modern research were expected to lay on compatibility mechanism and development of new drug based on the herb pair.

关 键 词：药对 配伍机制 物质基础 药动学 中药新药研发 

分 类 号：R283.31[医药卫生—中药学]