饮食疗法在儿童孤独症谱系障碍中的应用  

Dietary therapy in children with autism spectrum disorder

作　　者：陈燕惠[1] 卢洪珠 郑杰[1] 许莹[1] 

机构地区：[1]福建医科大学附属协和医院癫痫中心,福州350001

出　　处：《国际儿科学杂志》2017年第11期773-776,共4页International Journal of Pediatrics

摘　　要：孤独症谱系障碍（autism spectrum disorder，ASD）是导致儿童残疾的严重神经发育障碍性疾病，缺乏有效的治疗方法。其具体发病机制未明，目前认为是多种因素共同作用的结果。近年来，研究发现ASD儿童存在胃肠道问题，并且发现某些特殊的饮食疗法可减轻ASD症状。涉及ASD的饮食疗法，包括无谷胶饮食、去敏感或有害食物疗法、生酮饮食。ASD患者存在着胃肠道炎症或过敏、能量代谢紊乱、氧化应激损伤、神经递质紊乱、肠道菌群失衡。饮食疗法可能通过纠正上述紊乱而达到改善ASD症状的作用。该文就目前饮食疗法在儿童ASD的应用、相关机制及对儿童生长发育的影响作一综述。Autism spectrum disorder （ASD）is a severe neurodevelopmental disorder of children that leads to disability which lacks of effective treatment. The specific pathogenesis of ASD remains unclear, which may involve in multiple factors. In recent years, many studies have shown that children with ASD have gastroin- testinal（GI） abnormalities and some special diet therapies can effectively ameliorate the symptoms of ASD. These diets include gluten free diet, sensitive or harmful food removing therapy and ketogenic diet. The patients with ASD have GI inflammation or allergy, energy metabolism disorder, oxidative stress injury, neurotransmitter disturbance and dysbiosis of intestinal flora. Diet therapy may improve ASD symptoms by correcting disorders a- bove. This article reviews the application and the related mechanism of diet therapy in ASD children and the effect of diet therapy on the growth and the development of children.

关 键 词：饮食疗法 孤独症谱系障碍 JL童 

分 类 号：R749.94[医药卫生—神经病学与精神病学]