Prevalence of Decreased Susceptibility of Cryptococcus spp. Isolates to Fluconazole in Urban Sources of Presidente Prudente  

作　　者：Camila Marcon Caroline Lucio Moreira Daniela Adelia Femandes Inocencio Larissa Rodrigues de Oliveira Mariana Polidorio Kato Joyce Marinho de Souza Marcus Vinicius Pimenta Rodrigues Daniela Vanessa Moris 

机构地区：[1]The Department of lmmunology and Microbiology, University of Western Sao Paulo, Sao Paulo 19050-920, Brazil

出　　处：《Journal of Pharmacy and Pharmacology》2017年第12期891-897,共7页药剂与药理学（英文版）

摘　　要：The genus Cryptococcus is composed of encapsulated yeasts that have the ability to infect and cause disease in humans, as Cryptococcus gattii/Cryptococcus neoformans species complex. Facing the current research panel, few studies about cryptococcosis and epidemiological data have been carded out in the western region of Sao Paulo state. This study aimed to verify the occurrence of Cryptococcus spp. In public areas of the city of Presidente Prudente, using pigeon droppings and tree hollows as an environmental source. The samples were identified by conventional mycological methods. Were collected 54 samples from pigeon droppings and 62 samples from tree hollows of the genus Licania. And of these samples, 47 （87.0%） and 14 （22.5%） had positive growth of yeast from pigeon droppings and tree hollows, respectively. Cryptococcus was identified in 11 （20.4%） of the samples from pigeon droppings and 3 （21.4%） of those from tree hollows. The following species were identified： Cryptococcus neoformans （7.15%）, Cryptococcus laurentti （14.28%）, and Cryptococcus albidus （78.57%）. Decreased susceptibility to fluconazole was observed for some isolates. Fluconazole exhibited a limited in vitro activity, particularly against Cryptococcus albidus and Cryptococcus laurentii. Identification and susceptibility testing of Cryptococcus spp. should be performed on a routine basis in view of their unpredictable susceptibility profiles.

关 键 词：Droppings pigeons （Columba livia） tree hollows in vitro Cryptococcus spp. susceptibility test. 

分 类 号：R0[医药卫生]