重型抑郁症患者血清维生素D水平的研究  

Serum Vitamin D Level in Patients with Major Depressive Disorder

作　　者：金川云 胡建德 

机构地区：[1]上海市浦东新区南汇精神卫生中心,201399

出　　处：《中国健康心理学杂志》2017年第11期1601-1604,共4页China Journal of Health Psychology

摘　　要：目的:探讨重型抑郁症患者血清中维生素D水平及与抑郁病情的相关。方法:检测107名重型抑郁症患者(研究组)和121名健康体检者(对照组)的血清25-羟基维生素D[25(OH)D]的浓度,应用汉密顿抑郁量表(HAMD)评估抑郁症患者的抑郁程度。对重型抑郁症患者血清维生素D水平与患者的身高、肥胖指数、HAMD评分、复发次数及疾病持续时间进行相关性分析。结果:重型抑郁症患者血清25(OH)D浓度显著低于对照组(t=10.68,P<0.001);重型抑郁症患者维生素D缺乏率和不足率显著高于对照组(χ2=167.5,P<0.001);重型抑郁症患者血清25(OH)D水平与HAMD评分、疾病持续时间呈负相关(r=-0.81,-0.77;P=0.007,0.031),与身高、肥胖指数、复发次数不相关。结论:重型抑郁症患者的血清维生素D处于较低水平,为维生素D缺乏的高危人群;重型抑郁症患者维生素D水平与抑郁症状和病程呈负相关;对重型抑郁症患者进行维生素D水平检测和维生素D补充是必要的。Objective：To acquaintance the serum vitamin D level of patients with major depressive disorder and ex- plore the correlation between the serum vitamin D level and related conditions of major depressive disorder.Methods： The vitamin D level was detected in 107 patients with major depressive disorder and 121 healthy persons;The degree of depression of patients with major depressive disorder were assessed with 24--item Hamilton（HAMD）, and the correlation between the serum vitamin D level and height, HAMD score, relapses and disease course were analyzed. Results：The level of serum 25 （OH）D in major depressive disorder patients was significantly lower than that of healthy persons（t =-10.68 ,P〈0.001）;The rates of lack and less of serum vitamin D were significantly higher than those in the healthy persons（Z2：167.5, P〈0.001）.There were negative correlation between the serum 25 （OH）D and HAMD score, disease course in patients with major depressive disorder（r =-0.81 ,-0.77;P〈0.05） ;No correla- tion was found between the serum 25 （OH）D and height, H AMD score,BMI, relapses.Conclusion： Low serum levels of 25（OH）D in patients with major depressive disorder suggest that these patients are an important risk group for vitamin D deficiency;There are negative correlation between the serum vitamin D level and depression condition of patients with major depressive disorder;The research results indicate the need to monitor the concentration and sup- plementation of vitamin D in Major Depressive Disorder patients.

关 键 词：重型抑郁症 维生素D 汉密顿抑郁量表 肥胖指数 

分 类 号：R749.4[医药卫生—神经病学与精神病学]