黛力新与文拉法辛对放疗期间宫颈癌患者焦虑抑郁的早期影响  

The Early Effects of Deanxit and Venlafaxine Zyban in the Treatment of Patients of Cervical Carcinoma in Radiotherapy with Anxious and Depressive Symptoms

作　　者：邹蕴[1] 韩峰[2] 宛红娥[3] 夏宏娟 

机构地区：[1]新疆军区总医院放疗科,新疆乌鲁木齐830000 [2]新疆军区总医院药剂科 [3]新疆军区总医院影像中心

出　　处：《中国健康心理学杂志》2017年第11期1644-1647,共4页China Journal of Health Psychology

摘　　要：目的:探讨黛力新与文拉法辛缓释片对放疗期间宫颈癌患者焦虑抑郁的早期影响。方法:在我院确诊109例宫颈癌合并焦虑、抑郁患者按入院先后时间顺序,随机分为研究组56例与对照组53例,两组在常规治疗基础上分别予黛力新和文拉法辛缓释片行5周治疗观察。采用焦虑自评量表(SAS)、抑郁自评量表(SDS)评定治疗效果。评价不良反应采用副反应量表(TESS)。结果:两组治疗5周后,研究组SAS、SDS评分与治疗前比较下降显著,差异有统计学意义(t=-12.478,-12.457;P<0.01);对照组SAS、SDS评分与治疗前比较下降显著,差异有统计学意义(t=-16.717,-10.622;P<0.01)。两组TESS评分差异无统计学意义(t=-1.555,P=0.123),两组治疗中无明显不良反应出现。结论:黛力新、文拉法辛缓释片早期均具有较好的抗焦虑、抑郁作用,安全性有效,无明显不良反应。Objective：To investigate the early effects of Deanxit and Venlafaxine Zyban in the treatment of patients of cervical carcinoma in radiotherapy with anxious and depressive symptoms. Methods： According to hospitalization sequence, 109 patients of cervical carcinoma in radiotherapy with anxious and depressive symptoms were randomly divided into two groups,the study group（n =56, treated with Deanxit for 5 weeks）and the control group（n = 53, treated with Venlafaxine Zyban for 5 weeks）. SAS and SDS were used to assess the clinical＇efficacy, and the side effects were evaluated by TESS.Results： At the end of the 5 week, the SAS and SDS scores was dropped significantly in the study groups compared with pre--treatment data（t =-12.478,-12.457;P〈0.01）;The SAS and SDS scores was dropped significantly in the control groups compared with pre--treatment data（t =-16. 717 ,-10. 622;P〈0.01 ）. There were no statistically significant difference in two groups in the TESS scores, and no obvious adverse reaction in the two group treatments.Conclusion：Deanxit and Venlafaxine Zyban in the treatment of patients of cervical carcino- ma in radiotherapy with anxious and depressive symptoms are safe and effective and have no obvious adverse reac tion.

关 键 词：宫颈癌 焦虑 抑郁 黛力新 文拉法辛 

分 类 号：R749.053[医药卫生—神经病学与精神病学]