非何杰金氏淋巴瘤患者外周血T淋巴细胞亚群测定分析  

Assay of T Lymphocyte Subpopulations in Peripheral Blood of Patients with Non-Hodgkin Lymphoma

作　　者：苗锋[1] 李玉华[2] 李利华[3] 

机构地区：[1]中信重型机械公司中心医院内科,河南洛阳471003 [2]新乡医学院第一附属医院内科,河南卫辉453100 [3]郑州市第五人民医院内科,河南郑州450003

出　　处：《洛阳医专学报》2002年第3期200-201,共2页Journal of Luoyang Medical College

摘　　要：目的　测定中高度非何杰金氏淋巴瘤患者外周血T淋巴细胞亚群的数量。方法　采用酶免疫染色技术对 2 6例中高度非何杰金氏淋巴瘤患者外周血T淋巴细胞亚群进行测定并与 30例健康对照者进行比较。结果　患者组CD3下降 (P<0 0 1) ,CD4下降 (P <0 0 1) ,CD8升高 (P <0 0 1) ,CD4 /CD8下降 (P <0 0 1)。结论　中高度非何杰金氏淋巴瘤患者免疫失调 。Objective To assay the amount of T lymph oc yte subpopulations in peripheral blood of patients with intermediate and high gr ade non Hodgkin lymphoma. Methods The peripheral blood T lymphocyte subpopulations we re investigated by using enzymoimmunostaining in 26 patients with intermediate and high grade non Hodgkin lymphoma and in 30 normal subjects. Results The level of CD3?CD4 was lower in patients' group than that in normal controls( P <0 01) and the level of CD8 was higher in patients' gro up than that in normal controls( P <0.01).The ratio of CD4/CD8 was lower in patients than that in normal controls( P <0.01). Conclusions The results suggest that there is disturbance of i mmunologic balance and decrease of cellular mediate immunity in patients with in termediate and high grade non Hodgkin lymphoma.

关 键 词：T淋巴细胞亚群 非何杰金氏淋巴瘤 细胞免疫 

分 类 号：R733.1[医药卫生—肿瘤]