缺氧微环境诱导胶质母细胞瘤耐药机制研究进展  

Research progress on the mechanisms of chemotherapy resistance to glioblastoma induced by hypoxia microenvironment

作　　者：高雨歌 王韩兵[1] 张岩[1] 李里[1] 姜秋颖[1] 

机构地区：[1]哈尔滨医科大学附属第二医院肿瘤内科,哈尔滨市150001

出　　处：《中国肿瘤临床》2017年第21期1100-1103,共4页Chinese Journal of Clinical Oncology

基　　金：第57批中国博士后科学基金项目(编号:2015M571493)资助~~

摘　　要：胶质母细胞瘤(glioblastoma,GBM)的耐药性是导致其临床治疗失败的主要原因。目前,诸多研究认为肿瘤内部缺氧的微环境能够诱导GBM对放化疗的抵抗。GBM的生长极为迅速,贫瘠的氧供不能满足其对氧气的需求,缺氧的微环境由此形成。缺氧可通过不同机制影响GBM的耐药性。本文将根据缺氧微环境的形成与缺氧诱导GBM耐药的机制进行综述。The chemotherapy resistance of glioblastoma is one of the main reasons leading to treatment failure. To date, many studies suggest that hypoxia microenvironment can induce resistance to chemotherapy and radiotherapy. Glioblastoma cells grow fast, and poor oxygen cannot supply enough nourishment. Thus, hypoxia microenvironment occurs. However, hypoxia can affect chemotherapy resistance of glioblastoma through different kinds of mechanisms. In this review, we summarize the formation of hypoxic microenvironment and the pathogenesis of glioblastoma chemotherapy resistance induced by hypoxia.

关 键 词：胶质母细胞瘤 缺氧 微环境 化疗耐药 

分 类 号：R739.4[医药卫生—肿瘤]