舍曲林联合认知行为疗法治疗强迫症临床观察  

Clinical observation of sertraline combined cognitive behavior therapy in patients with obsessivecompulsive disorder

作　　者：范连梅 范瑞明[2] 宋秉琦 郭慧平 刘星 郭晋政 

机构地区：[1]山西省忻州市荣军精神病医院,034000 [2]遵义医学院,贵州遵义563000

出　　处：《中国实用医刊》2017年第20期88-91,共4页Chinese Journal of Practical Medicine

摘　　要：目的 评价舍曲林联合认知行为疗法治疗强迫症的治疗效果。方法 选取符合ICD-10诊断标准的108例强迫症患者随机分为治疗组（54例）和对照组（54例），疗程8周。治疗组采用舍曲林联合认知行为治疗，对照组单用舍曲林治疗，采用Yale-Brown强迫量表（Y-BOCS）、汉密尔顿焦虑量表（HAMA）评定疗效，药物不良反应量表（TESS）评定其不良反应。结果 在治疗第2、4、6和8周末，治疗组疗效优于对照组，差异有统计学意义（P〈0.01）。结论 舍曲林联合认知行为疗法治疗强迫症与单用舍曲林相比，起效快，疗效好，且安全性相当。Objective To compare the effect of sertraline combined with cognitive behavior therapy in patients with obsessive-compulsive disorder.Methods One hundred and eight patients with obsessive-compulsive disorder according with ICD-10 diagnostic criteria were randomly divtded into the therapeutic group（n=54） and the control group（n=54） and were treated for 8 weeks.The therapeutic group was given sertraline combined cognitive behavior therapy and the control group were given sertraline only. The clinical effect was assessed with the Yale-Brown Obsessive Compulsive Scale（Y-BOCS） and Hamilton A nxiety Scale（HAMA）, adverse events were assessed by the Treatment Emergent Symptom Scale（TESS）.Results At the end of 2, 4, 6, 8 weeks, the therapeutic efficacy of the therapy group was better than the control group, the difference was statistically significant（P〈0.01）.Conclusions Compared with single sertraline therapy, sertraline combined with cognitive behavior therapy has a guick therapeatic, effect, good curative effect and similar security.

关 键 词：强迫症 舍曲林 认知行为疗法 

分 类 号：R749.7[医药卫生—神经病学与精神病学]