乳腺癌FHIT表达及其临床价值的meta分析  

Expression and clinical significance of FHIT in breast cancer: a meta analysis

作　　者：张建祥[1] 王方[2] 袁博[2] 周亚楠[2] 胡泷[2] 姜文静[2] 宗红[2] 

机构地区：[1]郑州大学第一附属医院普外科,郑州450052 [2]郑州大学第一附属医院肿瘤科,郑州450052

出　　处：《郑州大学学报（医学版）》2017年第6期761-765,共5页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:系统评价FHIT蛋白在乳腺癌中的表达及临床意义。方法:检索中国知网、万方数据、维普网、Pubmed、Springer Link等数据库,按照纳入、排除标准选取文献,应用Rev Man 5.3.5.0及STATA 13.0软件对纳入的研究进行meta分析。结果:共纳入29篇文献,共计2 546例乳腺癌组织标本。Meta分析结果显示,乳腺癌组织中FHIT的表达低于乳腺良性病变组织[OR(95%CI)=0.12(0.06,0.23)]、癌旁正常组织[OR(95%CI)=0.05(0.02,0.11)]和正常组织[OR(95%CI)=0.06(0.02,0.14)];FHIT在乳腺癌Ⅰ-Ⅱ期中的表达高于Ⅲ-Ⅳ期[OR(95%CI)=2.51(1.87,3.38)]、肿瘤长径小于等于2 cm组高于大于2 cm组[P<0.01,OR=1.43,95%CI(1.10,1.84)]、高分化组高于低分化组[OR(95%CI)=2.18(1.33,3.57)]、无腋窝淋巴结转移组高于有转移组[OR(95%CI)=2.24(1.58,3.16)]、雌激素受体阴性组低于阳性组[OR(95%CI)=0.46(0.34,0.62)]、孕激素受体阴性组低于阳性组[OR(95%CI)=0.51(0.30,0.86)],患者不同年龄、绝经状态和组织分型中FHIT的表达差异无统计学意义。结论:FHIT表达缺失在乳腺癌发生、发展中起重要作用,与乳腺癌的临床病理特征有密切关系。Aim： To systematic evaluate the expression and clinical significance of FHIT in breast cancer. Methods：Literatures were searched in databases such as CNKI,Wanfang data,Weipu data,Pubmed and Springer Link. According to the inclusion and exclusion criteria,data were extracted. Then the data were analyzed by Rev Man 5. 3. 5. 0 and STATA13. 0 software. Results： A total of 29 literatures with 2 546 breast cancer tissue specimens were included. It was showed that the expression of FHIT was significantly different between breast cancer versus benign breast disease [OR（ 95% CI） =0. 12（ 0. 06,0. 23） ],breast cancer versus normal tissue adjacent to cancer [OR（ 95% CI） = 0. 05（ 0. 02,0. 11） ],breast cancer versus normal tissue [OR（ 95% CI） = 0. 06（ 0. 02,0. 14） ],stageⅠ-Ⅱ versus stage Ⅲ-Ⅳ [OR（ 95% CI） = 2. 51（ 1. 87,3. 38） ],size≤2 cm versus size 2 cm [OR（ 95% CI） = 1. 43（ 1. 10,1. 84） ],SBR 1-2 versus SBR 3 [OR（ 95%CI） = 2. 18（ 1. 33,3. 57） ],lymph node negative versus positive [OR（ 95% CI） = 2. 24（ 1. 58,3. 16） ],ER negative versus positive [OR（ 95% CI） = 0. 46（ 0. 34,0. 62） ],PR negative versus positive [OR（ 95% CI） = 0. 51（ 0. 30,0. 86） ].There were no significant differences between age 50 years versus age≥50 years,pre-menopausal versus post-menopausal,ductal versus lobular. Conclusion： Reduced expression of FHIT is closely related to carcinogenesis and progression of breast cancer. FHIT is closely related to the clinical and pathological characteristics of breast cancer.

关 键 词：乳腺癌 FHIT META分析 病例对照研究 

分 类 号：R737.9[医药卫生—肿瘤]