HPV与口咽部恶性肿瘤发病的相关性研究  

Study on the Correlation Between HPV and Pharyngeal Malignancy

作　　者：彭燕燕[1] 马锦霞[1] 陈乐川[1] 郑璟 

机构地区：[1]汕头市中心医院检验科PCR实验室,广东汕头515000

出　　处：《黑龙江医药》2017年第6期1201-1203,共3页Heilongjiang Medicine journal

基　　金：广东省汕头市科技计划项目(项目编号:0021935630813066)

摘　　要：目的:探究HPV与口咽部恶性肿瘤发病的相关性及HPV分型检测在口咽癌患者的治疗监测与预后判断中的意义。方法:随机选取我院行口咽癌手术患者98例,采集患者手术后口咽部组织标本、脱落细胞等作为观察组,同时采集患者癌旁正常组织标本、脱落细胞作为对照组,利用聚合酶链反应(PCR)及膜杂交法对目的基因进行快速、准确的提取、扩增及分型,应用统计学方法对检测结果进行分析比较。结果:通过检查发现HPV16、HPV18、HPV11三种亚型呈阳性,且观察组的阳性检出率明显高于对照组,HPV感染与肿瘤分化程度、性传播途径及预后有统计学意义。结论:HPV与口咽癌发病有明显相关性,对HPV感染的预防能够降低口咽癌发病率,同时对其预后有一定的帮助。Objective: To investigate the correlation between HPV and oral pharyngeal malignancies and the significance of HPV classification in the treatment of patients with oropharyngeal cancer. Methods: randomly selected from our line of 98 cases of patients with oropharyngeal cancer surgery, after surgery in patients with oropharyngeal tissue samples, such as exfoliated cells as observation group, and normal tissue adjacent to carcinoma specimens, exfoliated cells collected patients as control group, using the method of polymerase chain reaction(PCR) and hybridization of the target gene for rapid and accurate extraction, amplification and classification,application of statistical methods to analysis and comparison of test results. Results: through the inspection found HPV16, HPV18,HPV11 three subtypes were positive, and the positive detection rate of observation group was obviously higher than that of control group, HPV infection and tumor differentiation degree, sexual transmission and prognosis was statistically significant. Conclusion:HPV has a significant correlation with oropharyngeal carcinoma, and the prevention of HPV infection can reduce the incidence of oropharyngeal carcinoma, and it can be helpful to the prognosis.

关 键 词：HPV 口咽部 恶性肿瘤 

分 类 号：R739[医药卫生—肿瘤]