探究艾司西酞普兰与氟西汀治疗抑郁症的疗效和安全性  

Efficacy and Safety of Escitalopram and Fluoxetine in Clinical Treatment of Depression

作　　者：李益群[1] 

机构地区：[1]福建省泉州市第三医院,福建泉州362000

出　　处：《黑龙江医药》2017年第6期1276-1278,共3页Heilongjiang Medicine journal

摘　　要：目的:探究临床运用艾司西酞普兰、氟西汀在抑郁症治疗中的效果以及安全性。方法:选取本院在2014年12月至2015年12月间所收治的抑郁症80例患者作为临床对象,随机将其分成对照组、观察组。对照组予以氟西汀治疗,观察组予以艾司西酞普兰治疗,比较两组患者应用的临床疗效以及安全性。结果:经治疗之后,两组患者HAMD明显比治疗前低,其中观察组在1周的治疗之后评分明显的下降,而对照组自第2周之后才开始有明显的下降。待治疗完毕之后,两组患者HAMD的总分类似。结论:针对抑郁症的治疗艾司西酞普兰、氟西汀两种药物疗效比较接近,而艾司西酞普兰相对具有较快的起效速度并较少产生并发症,故在临床治疗的应用较为安全。Objective: This study was to explore the efficacy and safety of Escitalopram and Fluoxetine in clinical treatment of depression. Methods: Eighty patients with depression admitted to our hospital from December 2014 to December 2015 were selected as the study subjects, who were randomly assigned to the control group or observation group. The control group received treatment with Fluoxetine, and the observation group received treatment with Escitalopram. The two groups were compared for clinical efficacy and safety. Results: After treatment, the two groups of patients with HAMD was significantly lower than before treatment, which observation group after 1 week of treatment significantly decreased after the score,while the control group since the first 2 weeks after the beginning of a significant decline. After treatment was completed,there was no significant difference in the total score of HAMD between the two groups. Conclusion: Escitalopram and Fluoxetine produced comparable efficacy for the treatment of depression, while Escitalopram had quicker onset of action and was associated with less complications, indicating its better safety in clinical treatment.

关 键 词：艾司西酞普兰 氟西汀 抑郁症 疗效 安全性 

分 类 号：R749.4[医药卫生—神经病学与精神病学]