血小板衍生生长因子及其受体在胶质瘤发生发展中的研究进展  

Research advances in platelet - derived growth factor and platelet - derived growth factor receptor in the genesis and development of glioma

作　　者：毛峰 肖群根 王宝峰 郭东生[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院神经外科,武汉430030

出　　处：《中华实验外科杂志》2017年第12期2293-2295,共3页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金（81372711、81001116、81702480）

摘　　要：胶质瘤是源于神经上皮细胞的中枢神经系统原发肿瘤，具有无限制增殖及向周边正常脑组织广泛侵袭的特点。异常表达的血小板衍生生长因子（PDGF）及其膜受体（PDGFR）激活下游信号通路，影响人脑胶质瘤发生发展，但分子机制仍不清楚。PDGF、PDGFR在胚胎发育，细胞分化发挥着重要的作用。PDGF诱导胶质瘤动物模型为研究PDGF信号通路在胶质瘤发生发展中提供了重要的研究手段。现综述血小板衍生生长因子及其受体在胶质瘤发生发展中的作用。Gliomas are primary tumor originated from the gila] cells of the central nervous system, with the characteristics of unrestricted proliferation and widespread invasion to the surrounding normal brain tissue. The aberrant expression of the platelet- derived growth factor （PDGF） and its membrane receptor （PDGFR） activates the down- stream signaling pathway, which affects the development of human glioma, but the molecular mechanisms remain un- clear. PDGF and PDGFR play an important role in embryonic development and cell differentiation. PDGF - induced glioma animal mode] provides an important research method for the study of PDGF signaling pathway in the development of glioma. This article reviews the role of platelet - derived growth factor and its receptor in the development of glioma.

关 键 词：血小板衍生生长因子 血小板衍生生长因子受体 胶质瘤 动物模型 

分 类 号：R739.4[医药卫生—肿瘤]