重症急性胰腺炎病人细胞因子变化的临床意义  

The Clinical Significance of Cytokinic Abnormality in Severe Acute Pancreatitic Patients

作　　者：邵素凤[1] 曾元英[1] 

机构地区：[1]南京医科大学附属苏州医院ICU,苏州215001

出　　处：《临床急诊杂志》2002年第4期157-158,共2页Journal of Clinical Emergency

摘　　要：目的:探讨细胞因子与重症急性胰腺炎发病机理的关系。方法:采用双抗体夹心法ELISA检测重症急性胰腺炎病人发病第1、3、7天血清中IL-1β,IL-6和TNF-α的含量。结果:重症急性胰腺炎病人血清中3种细胞因子的含量均显著高于对照组,并于第3天时达高峰,第7天时随病情的好转而下降,但仍高于对照组。结论:重症急性胰腺炎的发病与IL-1β,IL-6和TNF-α等3种细胞因子的升高有关。Objective: To research the relationship between severe acute pancreatitis and cytokines. Methods: By using ELISA method to detect the level of IL-1 β, IL-6 and TNF-α in the serum of severe acute pancreatitic patients on 1st day. 3rd day and 7th day of test guoup. Results:The results were higher than that of control group. The cytokines levels on the third day were in high peak in all patients of this day. On the seventh day,when severe acute pancreatitis was getting improvement, the cytokines levels were also declined but still higher than those of control group. Conclusion: The onset of severe acute pan-creatitis is related to the higher cytokines of IL-1 β, IL-6 and TNF-α.

关 键 词：病理 急性胰腺炎 细胞因子 

分 类 号：R576.02[医药卫生—消化系统]