大肠杆菌与肺炎链球菌所致儿童化脓性脑膜炎临床特点对比分析  

The comparative analysis of clinical features of purulent meningitis in children caused by Escherichia coli and Streptococcus pneumoniae

作　　者：李海深 黄海波[1] 赖丹娜[1] 

机构地区：[1]信宜市人民医院,广东信宜525300

出　　处：《吉林医学》2017年第12期2207-2208,共2页Jilin Medical Journal

摘　　要：目的:对比大肠杆菌与肺炎链球菌所致儿童化脓性脑膜炎临床特点的差异性,为致病菌不明确情况下患儿的抗生素选择提供参考依据。方法:选取60例化脓性脑膜炎患儿的临床资料,根据病原学检查结果将其分为两组,大肠杆菌组28例,肺炎链球菌组32例,对两组患儿的临床特点进行对比分析。结果:大肠杆菌组化脑患儿以发病年龄<3个月,发中低热,抽搐的发生率明显高于肺炎链球菌组化脑患儿;而肺炎链球菌组化脑患儿发高热、意识障碍发生率明显高于大肠杆菌组化脑患儿,经比较,差异具有统计学意义(P<0.05)。两组患儿的辅助检查中,肺炎链球菌组化脑患儿WBC>12×109/L的发生率明显高于大肠杆菌组化脑患儿,经比较,差异具有统计学意义(P<0.05)。结论:大肠杆菌与肺炎链球菌所致儿童化脓性脑膜炎的临床特点存在明显差异性,发病年龄<3个月,发中低热、抽搐等特点可考虑是大肠杆菌感染,而发高热、意识障碍、WBC>12×109/L可考虑是肺炎链球菌感染,以此尽早选择合适的抗生素进行治疗。Objective To compare the difference of clinical characteristics between Escherichia coli and Streptococcus pneumoniae in children with purulent meningitis,and to provide reference for the selection of antibiotics in children with unclear pathogens. Method The clinical data of 60 cases of purulent meningitis was selected,according to the results of the etiological examination they were divided into two groups,28 cases of Escherichia coli group,Streptococcus pneumoniae group 32 cases,comparative analysis of the clinical characteristics of two groups of children. Results Escherichia coli group with brain age 3 months,hair fever,seizure incidence was significantly higher than that of Streptococcus pneumoniae and Streptococcus pneumoniae in children with purulent meningitis group,group of brain with high fever,consciousness disorder had a significantly higher incidence of Escherichia coli meningitis group were compared,the difference was statistically significant（P〈0. 05）. Assistant examination of the two groups of children with Streptococcus pneumoniae meningitis in children with WBC 12 × 109/L group was significantly higher than that of Escherichia coli meningitis in children group,by comparison,the difference was statistically significant（P〈0. 05）. Conclusion The clinical characteristics of Escherichia coli and Streptococcus pneumoniae in children caused by pyogenic meningitis have obvious differences,the onset age of 3 months,hair fever,convulsions and other characteristics can be considered the infection of Escherichia coli,WBC 12 × 109/L,high fever and disturbance of consciousness,could be considered to be a Streptococcus pneumoniae infection,in order to choose the appropriate antibiotics as soon as possible treatment.

关 键 词：大肠杆菌 肺炎链球菌 儿童化脓性脑膜炎 

分 类 号：R742.9[医药卫生—神经病学与精神病学]