细胞焦亡与眼病  

Pyroptosis and eye disease

作　　者：金鑫[1] 张红[1] 

机构地区：[1]哈尔滨医科大学附属第一医院眼科分院哈尔滨医科大学,150006

出　　处：《中华实验眼科杂志》2017年第12期1130-1133,共4页Chinese Journal Of Experimental Ophthalmology

基　　金：国家自然科学基金项目（81671844）

摘　　要：焦亡是一种近些年发现并且经过验证的新的程序性死亡方式，其特点为快速的细胞膜破裂以及细胞内炎性因子的释放。焦亡在细胞内细菌的清除中起着至关重要的作用，但也可能参与自发炎症和自身免疫性疾病的病理过程。细胞焦亡存在于许多眼病的发生、发展及消亡中。年龄相关性黄斑变性（AMD）、白内障、干眼、蚕食性角膜溃疡以及急性青光眼中关于细胞焦亡的研究已经初露头角，随着研究的深入，可能对这些眼病的认识达到更深层次的水平。本文就细胞焦亡的概念及其在AMD、白内障、干眼、蚕食性角膜溃疡和急性青光眼中的应用进展进行综述。Pyroptosis is a new programmed cell death which has been found recently. Pyroptosis features rapid plasma-membrane rupture and release of pro-inflammatory intracellular contents. Pyroptosis plays a vital role in intracellular bacterial clearance,but may also be involved in the pathological process of inflammatory and autoimmune diseases. It exists in the occurrence,development and dying of many eye diseases. The researches of pyroptosis in age- related macular degeneration （AMD） , cataract, dry eye disease, Mooren＇s ulcer and acute glaucoma have emerged, an in-depth research may be useful in understanding eye diseases in a deeper level. In this artile, the concept of ovrootosis and its involvement in AMD,cataract,dry eye disease,Mooren＇s ulcer and acute glaucoma are reviewed.

关 键 词：细胞焦亡 年龄相关性黄斑变性 白内障 干眼 蚕食性角膜溃疡 急性青光眼 

分 类 号：R77[医药卫生—眼科]