单、多b值DWI与乳腺不同病变类型的相关性研究  

Study on correlation between single b-value and multiple b-value DWI and different types of breast lesions

作　　者：王高燕[1] 董海波[1] 王洁[1] 傅丽晖[1] 王波[1] 陈士勇[2] 

机构地区：[1]宁波市医疗中心李惠利医院放射科,浙江宁波315041 [2]宁波市医疗中心李惠利医院东部院区医品部,浙江宁波315040

出　　处：《实用放射学杂志》2017年第12期1855-1858,共4页Journal of Practical Radiology

摘　　要：目的 探讨单、多b值扩散加权成像（DWI）与乳腺不同病变类型的相关性。方法 回顾性分析经病理证实且同时行单、多b值DWI检查的92例患者资料,其中囊肿8例，肉芽肿性炎11例，良性结节病灶33例，恶性肿瘤40例。取患者正常侧乳腺纤维腺体作为对照。获得单指数模型参数：表观扩散系数（ADC）。双指数模型参数：慢速表观扩散系数（ADCslow），快速表观扩散系数（ADCfast），快速扩散成分所占比例（ffast）。乳腺不同病变的ADC，ADCslow，ADCfast，ffast值采用单因素方差分析。采用LSD-t检验对乳腺不同病变组的参数平均值两两比较。结果 乳腺病变的ADC、ADCslow值从大到小依次为囊肿（2.369±0.380）×10-3 mm2/s、（1.294±0.439）×10-3 mm2/s，正常腺体（1.785±0.298）×10-3 mm2/s、（0.946±0.321）×10-3 mm2/s，良性肿瘤（1.647±0.296）×10-3 mm2/s、（0.944±0.256）×10-3 mm2/s，恶性肿瘤（1.146±0.191）×10-3 mm2/s、（0.584±0.139）×10-3 mm2/s，乳腺炎（1.062±0.231）×10-3 mm2/s、（0.567±0.115）×10-3 mm2/s。恶性组的ADCfast值（4.445±1.616）×10-3 mm2/s，明显高于其他各组，差异有统计学意义。恶性组的ffast值0.364±0.148，明显低于良性组，正常腺体，囊肿。炎性组的ADCfast值（3.321±0.660）×10-3 mm2/s，明显低于恶性组，且差异有统计学意义，但ADC，ADCslow，ffast值均无明显差异。结论 多b值DWI各参数相比单b值DWI参数更能体现乳腺各病变的病理特征。ADCfast值对乳腺炎和乳腺癌有更好的诊断及鉴别诊断价值。Objective To investigate the relationship between single b value and multiple b-value diffusion weighted imaging （DWI） and different types of breast lesions.Methods The data of 92 cases including 8 cases of cyst,ll cases of granulomatous inflammation,33 cases of benign nodules lesions and 40 cases of malignant tumor were analyzed retrospectively, who underwent single b-value DWI and multiple b-value DWI and all patients were confirmed by pathology.The normal side of the mammary gland fiber was taken as the control group.Apparent diffusion coefficient{ ADC） were obtained by the monoexponential model. Stow apparent diffusion coefficient（ADCslow ）, fast apparent diffusion coefficient{ ADCfast ）, the fraction of fast ADC（ffast ） were obtained by the biexponential model. ADC, ADCslow, ADCfast ffast values of different breast lesions were analyzed by single factor analysis of variance. The LSD-t test was used to compare the mean values of the parameters of the breast lesions in pairs. Results The ADC and ADCslow value of breast lesions were decreased in the order of cyst （2.369±0.380） × 10-3 mm2/s, （1.294±0.439） × 10 3 mm2/s,normal gland （1.785±0.298） × 10-3 mm2/s, （0.946±0.321 ） × 10-3 mm2/s, benign tumor （1.647~0.296}）×10 3mm2/s,（0.944±0.256） × 10-3mm2/s,malignant tumor（1.146±0.191）×10 3mmZ/s, （0.584±0.139） ×10-3mm2/s and mastitis（1.062±0.231） × 10 3 mm2/s, （0.567±0.115） × 10 3 mm2/s. The ADCfast value of malignant group（4.445± 1.616） × 10 3 mm2/s was significantly higher than that of other groups, and the difference was statistically significant.The ffast value of malignant group 0.364t 0.148 was significantly lower than that of benign group, normal gland and cyst. ADCfast value in the inflammatory group （3.321 ±0.660 ） × 10-3 mm2/s was significantly lower than that in the malignant group, and the difference was statistically significant. There was no significant difference in ADC,ADCslow and ffast. Conclusion Compared with the si

关 键 词：乳腺肿瘤 扩散加权成像 表观扩散系数 双指数模型 

分 类 号：R737.9[医药卫生—肿瘤] R445.2[医药卫生—临床医学]