miR-21对血管内皮功能及血管生成调节作用的研究进展  

Advances on studies of miR-21 in vascular endothelial function and angiogenesis

作　　者：谭晓勇 方丹 吴剑波 罗茂 

机构地区：[1]西南医科大学药物研究中心,四川泸州646000 [2]宣汉县人民医院药学部,四川达州635000

出　　处：《中国病理生理杂志》2017年第12期2299-2304,共6页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81570263);四川省教育厅重点项目(No.16ZA0178);泸州市科技局资助项目(No.2016LZXNYD-J24;No.2016-R-70(11/24);No.2016-R-70(8/24)

摘　　要：血管内皮细胞作为血管的内衬,一方面参与构成血管的通透性屏障,调节液体、气体及生物大分子物质的选择性通透;另一方面可分泌大量血管活性因子,参与对凝血与抗凝功能、纤溶系统和炎症发生发展等的调控,与血管功能和循环系统的稳定密切相关。研究表明,血管内皮细胞功能激活是血管生成的先决条件^（[1]）。血管内皮细胞在多种细胞因子的诱导下增殖迁移,为血管管腔形成提供内皮细胞数量的积累。MicroRNAs （miRNAs） are a class of non-coding, endogenous, single-stranded small RNA mole-cules composed of 19 ~25 nucleotides. miRNAs are widely involved in the process of human life activities. Recent studies have shown that part of miRNAs regulate the vascular endothelial function and angiogenesis. High expression of miRNA-21 is found to play important roles in the cell proliferation, cell apoptosis, cell growth and death of vascular endothelial cells. This review will focus on the recent progress related to miRNAs in vascular endothelial function and angiogenesis, providing a new insight in cardiovascular disease prevention, clinical diagnosis, prognosis and target therapeutics.

关 键 词：微小RNA-21 血管内皮细胞 血管生成 心血管疾病 

分 类 号：R0[医药卫生] R363