胃癌患者血清中DKK-1、HE4、PARP-1水平与胃癌临床分期、淋巴结转移度及临床预后的关系  

The relationship between serum Dickkopf-1,HE4 and PARP-1 levels and clinical staging of gastric cancer and lymph node metastasis and its clinical prognosis

作　　者：许琦华 

机构地区：[1]上海中医药大学附属第七人民医院,上海200137

出　　处：《国际检验医学杂志》2017年第23期3219-3221,共3页International Journal of Laboratory Medicine

基　　金：浦东新区卫生系统学科带头培养计划(PWRd 2016-12);上海中医药大学附属第七人民医院人才培养计划(XX2017-07;BDX2016-01)

摘　　要：目的探讨胃癌患者血清中Dickkopf-1(DKK-1)、人类附睾蛋白-4(HE4)、聚腺苷酸二磷酸核糖转移酶-1(PARP-1)水平与胃癌临床分期、淋巴结转移度及患者临床预后的关系。方法应用酶联免疫吸附法(ELISA)检测128例胃癌患者和50例健康对照组的血清中DKK-1、HE4、PARP-1水平,分析其与患者胃癌临床分期、淋巴结转移度、临床预后的关系,并探讨血清中DKK-1、HE4、PARP-1水平与患者临床预后的关系。结果胃癌患者血清DKK-1、HE4、PARP-1水平分别为(29.6±9.6)、(52.6±18.6)、(6.1±1.8)μg/L,而健康对照组患者水平分别为(15.8±1.5)、(17.5±2.6)、(3.6±1.8)μg/L,胃癌组的血清DKK-1、HE4、PARP-1水平明显高于健康对照组,差异有统计学意义(P<0.05);年龄越高、分化程度越低、临床分期晚、伴有淋巴结转移的患者血清中DKK-1、HE4、PARP-1水平更高,差异有统计学意义(P<0.05);血清中DKK-1、HE4、PARP-1与患者性别、年龄无相关性,而与TNM分期、淋巴结转移度呈正相关,DKK-1、HE4、PARP-1是胃癌患者预后不良的独立危险因素。结论胃癌患者中血清DKK-1、HE4、PARP-1水平与患者临床预后密切相关,是患者预后不良的独立危险因素。Objective To investigate the relationship between serum Dickkopf-1, HE4 and PARP-1 levels and clinical staging of gastric cancer and lymph node metastasis and its clinical prognosis. Methods The serum levels of DKK-1, HE4 and PARP-1 in 50 patients with gastric cancer （gastric cancer group） and 50 healthy volunteers （control group） were measured by enzyme-linked im-munosorbent assay （ELISA ）, the relationship between serum Dickkopf-1, HE4 and PARP-1 levels and clinical staging of gastric cancer,lymph node metastasis was analyzed, and the clinical prognosis was explored. Results Serum DKK-1, HE4, PARP-1 levels of gastric cancer group were （29. 6 ＋ 9. 6） ,（52. 6 ＋ 18. 6） ,（6. 1 ＋ 1. 8）jng/L respectively, and the levels of control group were （5.8 土 1. 5）,（17. 5±2. 6）,（3. 6±1. 8）jug/L respectively. Serum DKK-1, HE4 and PARP-1 levels of gastric cancer group were signifi-cantly higher than those of control group,DKK-1, HE4 , PARP-1 levels were higher in gastric cancer patients with older age, lower degree of differentiation, in late clinical stage,and with lymph node metastasis ; serum DKK-1, HE4 , PARP-1 levels had no obvious relationship with gender and age but were positively related to TNM stage,and lymph node metastasis; DKK-1 （P =0. 04） , HE4 （P =0. 03） and PARP-1 （P = 0. 04） are independent risk factors of poor prognosis of patients with gastric cancer. Conclusion The levels of serum Dickkopf-1, HE and PARP-1 in patients with gastric cancer are closely related to the clinical prognosis of the pa-tients and are independent risk factors of poor prognosis.

关 键 词：胃癌 淋巴结转移 临床分期 预后 

分 类 号：R730.43[医药卫生—肿瘤] R735.2[医药卫生—临床医学]