T细胞免疫球蛋白和黏蛋白3基因rs4704853G/A多态性及与胰腺癌易感相关性  

T-cell immunoglobulin-and mucin-domain-containingmolecule 3 gene rs4704853G/A polymorphism and its association with susceptibility to pancreatic cancer

作　　者：佟大年[1] 周尊强[1] 张正筠[1] 关蛟 周光文[1] 

机构地区：[1]上海交通大学附属第六人民医院普通外科,上海200233

出　　处：《哈尔滨医科大学学报》2017年第5期442-445,共4页Journal of Harbin Medical University

基　　金：中国博士后科学基金(2015M580270);黑龙江省博士后科学基金(LBH-Zl5129);哈尔滨医科大学附属第二医院中青年创新科学研究基金(CX2016-19)

摘　　要：目的研究汉族人群中T细胞免疫球蛋白和黏蛋白3(Tim-3)基因rs4704853G/A多态性与胰腺癌的易感性。方法检测和对比126名汉族胰腺癌患者和156名汉族健康对照人群中Tim-3基因rs4704853G/A多态性的比例,并检测此多态性对血清Tim-3水平的影响。结果 rs4704853GA基因型在胰腺癌患者中占比22.2%,明显高于健康对照组(占比10.2%),具有统计学意义(OR 2.50,95%CI,1.28~4.87,P=0.006)。等位基因A的出现频率在患者中也显著高于对照组(OR 2.31,95%CI,1.22~4.38,P=0.008)。进一步层化分析显示,rs4704853G/A多态性在有周围血管浸润的患者中的出现频率明显高于未有血管浸润的患者(OR 4.03,95%CI,1.18~13.78,P=0.018)。而探究此多态性的潜在功能发现,含GA基因型的个体的血清Tim-3水平显著高于GG基因型的个体(P<0.01)。结论 Tim-3基因的rs4704853G/A多态性与中国汉族人群的胰腺癌易感性具备相关性,且可能促进Tim-3的表达。Objective To investigate the association between T-cell immunoglobulin- and mu- cin-domain-containingmolecule 3 （Tim-3） gene rs4704853G/A polymorphism and pancreatic cancer in the Han Chinese population. Methods Tim-3 gene rs4704853G/A polymorphism in 126 pancreatic cancer patients and 156 healthy controls from the Han Chinese were examined and analyzed. Serum Tim-3 level of the subjects was also examined. Results rs4704853GA genotype accounted for 22.2%o in the pancreatic cancer patients and was significantly higher than that in the healthy controls （10.2% , OR 2.50, 95% CI, 1.28 -4. 87, P =0. 006）. Similarly, rs4704853A allele frequency was increased patients than in controls （OR 2.31, 95% CI, i. 22 - 4.38,P = 0. 008）. Further stratification analysis showed that rs4704853A allele frequency was significantly higher in patients with vascular infiltration compared with those without vascular infiltration （ OR 4. 03, 95% CI, 1.18 - 13.78, P = 0. 018）. Serum Tim-3 level was significantly higher in subjects carrying GA genotype compared with those with GG genotype. Conclusion Tim-3 gene rs4704853G/A polymorphism is associated with increased risk of pancreatic cancer in the Han Chinese population, and could increase gene expression.

关 键 词：T细胞免疫球蛋白和黏蛋白3 多态性 胰腺癌 

分 类 号：R735.9[医药卫生—肿瘤]