广泛性焦虑障碍患者全脑皮层厚度和静息态功能连接的脑影像研究  

Alternations in cortical thickness and functional connectivity in patients with generalized anxiety disorder

作　　者：李伟[1] 崔慧茹[1] 朱智佩 李惠[1] 胡强 张兰兰[2] 李建奇[3] 杨志 王继军 李春波 

机构地区：[1]上海市重性精神病重点实验室,上海市精神卫生中心,上海交通大学医学院,上海200030 [2]苏州市广济医院,苏州215000 [3]上海市磁共振重点实验室,华东师范大学物理系,上海200000 [4]教育部上海交通大学Bio-X研究所,上海200000 [5]上海交通大学脑科学与技术研究中心,上海200000

出　　处：《中华行为医学与脑科学杂志》2017年第11期989-993,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目（81071098）;国家临床重点专科建设资助项目（OMA-MH,2011-873）;上海市卫生系统优秀学科带头人培养计划（XBR2011005）;国家留学基金委奖学金项目（CSCNO.201606230115）;上海市卫生局青年项目（20164Y0215）;上海市精神卫生中心院级基金初级项目（2016-YJ-03）

摘　　要：目的研究广泛性焦虑障碍（generalizedanxietydisorder，GAD）患者全脑灰质皮层厚度改变，并探索相关静息态功能连接变化。方法提取21例GAD患者及与之匹配的22例正常对照的结构像和睁眼静息态数据，采用FreeSurfer软件对灰质皮层厚度进行全脑探索性分析，并以厚度异常的脑区采用DPABI软件进行感兴趣区功能连接分析。结果GAD组的右侧额中回喙部（MNI坐标：x=27．9，Y：53．4，z=-11．1；面积：241．93mm2；FDR校正，P〈0．1）及右侧颞下回MNI坐标：x=49．7，Y=-57．8，Z=-8．7；面积：138．93mm2；FDR校正，P〈O．1）较正常对照组皮层厚度增加。右侧额中回喙部与右侧枕上回、右侧枕中回及右侧中央前回的功能连接，GAD组较正常对照组减弱（AlphaSim校正，P〈0．05）；与右侧角回的功能连接，GAD组较正常对照组增强（AlphaSim校正，P〈0．05）。结论额中回喙部在GAD的病理机制中具有重要作用，可作为今后临床物理治疗的刺激靶点来改善焦虑症状。Objective To investigate the changes of cortical thickness and relative resting state functional connectivity in patients with generalized anxiety disorder （GAD）. Methods The present study analyzed structural and eyes-open resting state functional MRI were performed in 21 patients with GAD and 22 matched healthy controls. Cortical thickness was estimated with FreeSurfer. The structurally altered re- gions were defined as region of interest （ROI） to analyze functional connectivity （FC） using resting state functional MRI data by DPABI. Results Cortical thickness of patients with GAD were increased in right rostra1 middle frontal gyrus （rMFG; MNI：x=27.9,y=53.4,z=-11.1 ; size： 241.93 mm2 ; FDR corrected,P 〈0.1） and right inferior temporal gyrus （IGT; MNI：x=49.7,y=-57.8,z=-8.7;size：138.93 mm2;FDR corrected,P〈0.1 ） compared with heahhy controls. FC between right rMFG and right superior/middle occipi- tal gyrus as well as well as FC between rMFG and right precentral gyrus showed decreased in patients with GAD compared with healthy controls （AlphaSim corrected,P〈0.05）. FC between fight rMFG and right angu- lar gyrus showed increased in patients with GAD compared with healthy control （AlphaSim corrected, P〈 0.05）. Conclusion The rMFG may play an important role in the pathophysiology of GAD, which can be used as an stimuli target in physicotherapeutics to improve anxiety symptoms.

关 键 词：广泛性焦虑 皮层厚度 功能连接 额中回喙部 磁共振 

分 类 号：R749.72[医药卫生—神经病学与精神病学]