髓样抑制细胞与消化系统肿瘤关系的研究进展  

Advances in the relation between myeloid derived suppressor cells and digestive system tumors

作　　者：黄颖滨 邰强[1] 焦兴元[1] 

机构地区：[1]中山大学附属第一医院器官移植中心,广州510080

出　　处：《中华消化外科杂志》2017年第12期1260-1264,共5页Chinese Journal of Digestive Surgery

基　　金：国家自然科学基金面上项目（81270531）;广东省自然科学基金（S2013010015475）

摘　　要：髓样抑制细胞（MDSC）是一种肌源性干细胞，在肿瘤源性细胞因子作用下产生，其自身有免疫抑制作用．也能通过多种机制介导T淋巴细胞的免疫抑制功能。近年的研究结果表明：MDSC参与肿瘤免疫逃逸、免疫耐受等病理过程，在促进肿瘤发生、发展方面起重要作用。笔者就MDSC的产生及其免疫抑制作用机制、MDSC与食管癌、胃癌、结直肠癌、肝细胞癌、胆囊癌、胰腺癌等消化系统肿瘤关系的研究进展作一综述。Myeloid derived suppressor cell （MDSC） is a kind of myogenic stem cells that are induced by tumor-derived cytokines. MDSCs not only have their own immunosuppressive effects, but also can mediate the immunosuppressive effects of T lymphocytes through different mechanisms. Recent studies have shown that MDSCs involved in tumor immune escape, immune tolerance as well as other pathological processes, and played an important role in promoting the generation and development of tumors. The advances of the generation, immunosuppressive effects of MDSCs and their relation with digestive system tumors were summarized in this paper, which would provide evidences for the clinical use of MDSCs in treating digestive system tumors.

关 键 词：消化系统肿瘤 髓样抑制细胞 免疫抑制 靶点 

分 类 号：R735[医药卫生—肿瘤]