血清尿酸在双相情感障碍中的检测价值  

Detection value of serum uric acid in bipolar disorder

作　　者：王勇 张克波 

机构地区：[1]广元市精神卫生中心检验科,四川广元628000 [2]四川大学华西医院精神医学研究室,四川成都610041

出　　处：《西部医学》2017年第12期1762-1765,1769,共5页Medical Journal of West China

基　　金：国家自然科学基金(81171275)

摘　　要：目的探讨血清尿酸水平在双相情感障碍中的检测价值,包括生物标记价值与状态标记价值。方法选取2013年5月~2016年2月接受治疗的322例双相情感障碍患者作为观察组,按照患者个人病历及杨氏躁狂量表、汉密尔顿抑郁量表评分,将197例躁狂发作患者纳入躁狂组,将125例抑郁发作患者纳入抑郁组。同时按照患者精神科药物使用情况,将241例患者纳入未用药组,将81例患者纳入用药组。另同期选择进行治疗的77例首发精神分裂症患者,将其纳入精神分裂组,同时选择行健康体检的322例健康成人,纳入健康对照组。比较所测各组血清尿酸水平差异,患者血清尿酸水平与双相情感障碍症状的相关性。结果用药组患者血清尿酸水平略高于未用药组,差异无统计学意义(P>0.05)。观察组血清尿酸水平明显高于精神分裂组,差异具有统计学意义(P<0.05)。观察组及精神分裂组血清尿酸含量均明显高于对照组差异具有统计学意义(P<0.05)。躁狂组血清尿酸水平明显高抑郁组患者,差异具有统计学意义(P<0.05)。躁狂组及抑郁组患者血清尿酸含量均明显高于对照组,差异具有统计学意义(P<0.05)。双相情感障碍躁狂组患者杨氏躁狂量表评分21~50,中位数为36(31,39)分,血清尿酸水平与躁狂发作无相关性(r=0.09,P>0.05)。双相情感障碍抑郁组患者汉密尔顿抑郁量表评分17~45,中位数为32(23,38)分,血清尿酸水平与抑郁发作无相关性(r=-0.26,P>0.05)。结论临床医生可通过检查血清尿酸水平作为其生物标记物用以双相情感障碍患者的初筛,但不可以血清尿酸水平的高低作为双向情感障碍严重程度的指标。Objective To explore the detection value of serum uric acid level in bipolar disorder, including the val- ue of biomarkers and the value of the status marker. Methods Between May 2013 and February 2016, 322 patients with bipolar affective disorder were selected in our hospital, according to the individual patient medical records and the Young Mania Rating Scale, Hamilton depression scale. 197 cases of patients with manic episode were included in the manic group. 125 patients with depressive episode were included in the depression group. At the same time according to the pa tient psychiatric drug situation, 241 patients were included in the untreated group, 81 patients were included in the medi- cation group. In the same period, 77 patients with first episode schizophrenia selected in our hospital were included in the schizophrenic group. 322 cases of healthy adults for health examination in our hospital were included in the healthy con trol group. The correlation between serum uric acid level and the symptoms of bipolar disorder was observed and com- pared between the groups. Results The serum uric acid level in the treatment group （374.14 ± 104.75μmol/L） was slightly higher than the untreated group （339.42 ± 107.15μmol/L ）（P〉0.05）. The serum uric acid level in the obser- vation group （349.44± 106.2 μmol/L） was evidently higher than that of the schizophrenic group （318.81 ± 85.58μmol/ L） （P〈0.05）. The serum uric acid levels in the observation group and the schizophrenia group were evidently higher than those in the control group （P〈0.05）. Manic group of serum uric acid （365.54 ± 103. 11μmol/L） was evidently higher than that of depression group （321.45±107.68μmol/L） （P〈0.05）. Manic group and depression group patients serum uric acid levels were evidently higher than the control group （P〈0.05）. Bipolar affective disorder manic group of Young Mania Rating Scale scored between 21 to 50, with a median of 36 （31, 39）, serum uric acid level and mania

关 键 词：血清尿酸 双相情感障碍 检测价值 

分 类 号：R749.41[医药卫生—神经病学与精神病学]