血管球瘤10例临床病理分析  

Glomus tumor: a clinicopathological analysis of 10 cases

作　　者：付万垒[1] 郭乔楠[1] 

机构地区：[1]第三军医大学新桥医院病理科,重庆400037

出　　处：《局解手术学杂志》2017年第12期877-881,共5页Journal of Regional Anatomy and Operative Surgery

摘　　要：目的探讨血管球瘤的临床病理特征与诊断。方法回顾性分析第三军医大学新桥医院病理科诊断的10例血管球瘤的临床特征、病理形态学及免疫组化染色结果,并结合文献复习进行讨论。结果 10例患者中,女6例,男4例,平均年龄45.3岁,手指末端最常见。肿瘤呈圆形、卵圆形,表面呈灰红色,直径0.4~2.7 cm。典型病理形态学为肿瘤细胞呈圆形、卵圆形,瘤细胞大小较一致,胞浆呈透明或嗜酸性;瘤细胞异型性不明显,未见核分裂象;瘤细胞围绕薄壁血管呈血管外皮瘤样排列,少数病例间质可见黏液变性。免疫组化:Vimentin、SMA和Ⅳ型胶原均(+),而CgA、Syn、desmin、CD34、CK及S-100均(-)。10例血管球瘤均为良性,随访14~145个月无复发。结论血管球瘤是一种罕见的软组织肿瘤,罕见部位的血管球瘤不容易诊断,确诊依赖病理形态学及免疫组化检查相结合。Objective To study the clinicopathological characteristics, diagnosis,differential diagnosis,therapy and prognosis of glomus tumor. Methods The clinical and histopathological features and immunohistochemical phenotypes were retrospectively analyzed in 10 cases of glomus tumors, with review of the related literature. Results Of 10 patients,6 cases were female ,4 cases were male, mean age 45.3 years old. Glomus tumors commonly occurred in the end of fingers. We found that the shape of tumor was round or ovoid, and the tumor exhibited grey red. The size of these tumors ranged from 0.4 cm to 2.7 em in diameter. Microscopically, The tumor cells were uniform-sized,round or o- val ,with clear or eosinophilic cytoplasm. The atypia and mitotic activity of these tumors were not observed. The tumor cells arranged around the thin-walled blood vessels showing a hemangiopericytoma-like pattern. Myxoid change was seen in the stroma of glomus tumor. The tumor cells expressed Vimentin ,SMA and collagen 1V by immunohistochemical staining, but negative for CgA, Syn, desmin, CD34, CK and S-100. All 10 cases were benign, and had no evidence of the recurrence in follow-up for 14 to 145 months. Conclusion Glomus tumor is a very rare soft tissue tumor,and the atypical morphology of glomus tumors in unusual location may cause diagnostic difficulty. The diagnosis for glomus tumor depends mainly on histopathological features and immunohistochemical markers.

关 键 词：血管球瘤 诊断 鉴别诊断 免疫组化 

分 类 号：R738.6[医药卫生—肿瘤]