Ki-67在胃癌中的表达及其与氟脲嘧啶类化疗药的相关性  

THE EXPRESSION OF KI-67 IN GASTRIC CANCER AND ITS EFFECT ON THE FLUOROPYRIMIDINES DRUGS

作　　者：华云旗[1] 杨永岩[1] 金云剑 张文慧[1] 谭亚琴[1] 葛振昕 赵翠云[1] 赵美丽[1] 刘险峰[1] 

机构地区：[1]包头市肿瘤医院肿瘤内科,内蒙古包头014030

出　　处：《内蒙古医科大学学报》2017年第4期298-301,307,共5页Journal of Inner Mongolia Medical University

基　　金：内蒙古自治区卫生和计划生育委员会医疗卫生科研计划项目(201303124);内蒙古自治区自然科学基金(2016MS0899)

摘　　要：目的:探讨Ki-67在胃癌中的表达及其与氟脲嘧啶类化疗药的相关性。方法:收集本院病理诊断明确的胃癌病人资料69例,且满足术后以氟脲嘧啶类药物为主的联合化学治疗,免疫组织化学方法检测胃癌病人Ki-67的表达情况及其与氟脲嘧啶类化疗药的相关性。结果:胃癌病人Ki-67阳性表达率随腺癌分化程度变化,分化程度越低表达越高(P<0.05),淋巴结转移病人组阳性表达率高于非淋巴结转移组(P<0.05),且与胃癌浸润深度正相关(P<0.05);同时Ki-67表达阳性病人临床有效率和疾病控制率明显高于表达阴性病人(P<0.05),Ki-67表达阳性率与氟脲嘧啶类药物敏感性相关(P<0.05)。结论:Ki-67的表达与胃癌组织病理类型、淋巴结转移、分化程度及氟脲嘧啶类药物化疗敏感性相关,Ki-67的表达可作为氟脲嘧啶类药物临床化疗选择方案的预测因子。Objective：To investigate the expression of Ki-67 in gastric cancer and its effect on the fluoropyrimidines drugs.Methods：Retrospective analysis was carried out in 69 gastric cancer patients,who were treated on fluoropyrimidine based combined chemotherapy after operation.the expression of Ki-67 was detected by immunohistochemical method,statistical analysis its expression in gastric carcinoma and its effect on fluorouracil chemotherapy drugs.Results：In gastric cancer patients,the Ki-67 positive expression rate were gradually increased,with the decrease of the degree of differentiation of gastric cancer（P〈0.05）;Ki-67 positive expression rate in patients with lymph node metastasis was significantly higher than those in patients without lymph node metastasis（P〈0.05）;Positive rate of Ki-67 expression in invasive cancer was higher than those in less invasive cancer.（P〈0.05）.The clinical efficiency and disease control rate for gastric cancer patients with Ki-67 expression positive was significantly higher than that of patients with negative expression（P〈0.05）.The positive rate of Ki-67 expression in the two groups（sensitive for fluoropyrimidines drugs vs insensitive groups）was statistically significant（P〈0.05）.Conclusion：The expression of Ki-67 was correlated with the degree of differentiation,lymph node metastasis,infiltration depth and the sensitivity of fluoropyrimidines drugs.The expression of Ki-67 can be used as a predictive factor for the selection of fluoropyrimidines drugs.

关 键 词：胃癌 化疗 预测因子 氟脲嘧啶类药物 

分 类 号：R735.2[医药卫生—肿瘤]