益生菌及其制品治疗肠道易激综合征的研究进展  

A Review of Probiotics in the Treatment of Irritable Bowel Syndrome

作　　者：洪青[1] 刘振民[1] 王国娇[1] 杭锋[1] 

机构地区：[1]光明乳业股份有限公司乳业研究院,上海乳业生物工程技术研究中心,乳业生物技术国家重点实验室,上海200436

出　　处：《乳业科学与技术》2017年第5期28-31,共4页JOURNAL OF DAIRY SCIENCE AND TECHNOLOGY

基　　金：上海市科学技术委员会工程中心能力提升项目(16DZ2280600)

摘　　要：肠道易激综合征(irritable bowel syndrome,IBS)是一种常见的功能性胃肠道疾病,患者伴有腹痛、便秘或腹泻现象,严重影响其生活质量。益生菌能够调节肠道菌群平衡,加强肠道生物的屏障功能,参与免疫系统发挥作用,为治疗IBS提供了新思路。本文对采用益生菌治疗IBS的研究进展进行综述,阐明了IBS的亚型分类、IBS患者的肠道菌群变化以及益生菌治疗IBS的机制和效果,为益生菌治疗IBS提供参考,拓宽益生菌的应用范围。Irritable bowel syndrome （IBS） is a common gastrointestinal disorder that causes abdominal pain, diarrhea and constipation, reducing the quality of life in patients. Probiotics have been shown to regulate the intestinal fora balance, enhance intestinal barrier function and modulate the immune response, thereby providing new approaches to treat IBS. This article aims to review the literature concerning the treatment of IBS with probiotics with respect to the subtypes of IBS, changes in the intestinal fora of IBS patients, the therapeutical effect of probiotics on IBS and the underlying mechanism for the purpose of providing useful information for applying probiotics to treat IBS and broadening their scope of application.

关 键 词：益生菌 肠道易激综合征 腹泻 便秘 

分 类 号：R574.4[医药卫生—消化系统] TS201.3[医药卫生—内科学]