染料木黄酮对宫颈癌细胞增殖和侵袭的影响  

Effects of Genistein on the Proliferation and Invasion of Human Cervical Cancer Cells

作　　者：徐丛荣[1] 魏建威[1] 曾敏玲[1] 林琼花[1] 胡海霞[1] 

机构地区：[1]福建中医药大学附属第二人民医院检验科,福建省福州市350003

出　　处：《医学理论与实践》2017年第24期3618-3619,共2页The Journal of Medical Theory and Practice

基　　金：福建省自然科学基金(2015J01481)

摘　　要：目的:检测染料木黄酮(Genistein)对宫颈癌HeLa细胞增殖、迁移和侵袭的影响。方法:体外培养宫颈癌HeLa细胞,用MTT观察染料木黄酮对HeLa细胞增殖的影响;Transwell法观察染料木黄酮对细胞的迁移和侵袭能力的影响。结果:染料木黄酮作用后,宫颈癌HeLa细胞增殖能力明显低于对照组,差异具有统计学意义(P<0.05),Transwell实验结果显示宫颈癌HeLa细胞迁移和侵袭能力明显受到抑制,差异具有统计学意义(P<0.05)。结论:染料木黄酮在体外具有抑制HeLa细胞增殖、迁移和侵袭的作用。Objective：To study the effect of genistein on the proliferation、mimigration and invasion of cervical cancer cell line（HeLa）.Methods：MTT assay was used to detect the anti-proliferative of genistein on cervical cancer cell line（HeLa）.Transwell invasion assay was used to measure the mimigration and invasion.Results：The proliferation was significantly lower in geistein treated groups than those in the control groups（P〈0.05）;the numbers of invading and migrating cervical cancer cell line（HeLa）were significantly lower in geistein treated groups than those in the control groups（P〈0.05）.Conclusion：Genistein can inhibit the proliferation,mimigration and invasion of cervical cancer cell line（Hela）.

关 键 词：宫颈癌HELA细胞 染料木黄酮 增殖 侵袭 

分 类 号：R737.33[医药卫生—肿瘤]