不同剂量阿立哌唑对首发精神分裂症女性患者服用抗精神病药物致高泌乳素血症的治疗  

Effects of Different Doses of Aripiprazole on Antipsychotics Induced Hyperprolactinemia with First-episode Schizophrenia Females

作　　者：胡怡[1] 王琪珠 黄朝红[1] 陆香秀 鲍天昊[1] 

机构地区：[1]云南省精神病医院,云南昆明650224

出　　处：《昆明医科大学学报》2017年第12期89-92,共4页Journal of Kunming Medical University

基　　金：昆明市卫生科技人才培养项目暨"十百千"工程基金资助项目[2017-sw(后备)-65]

摘　　要：目的探讨不同剂量阿立哌唑对首发精神分裂症女性患者服用5种临床常用抗精神病药物所致高泌乳素血症的干预治疗效果.方法将300例首发女性精神分裂症患者分别使用利培酮、奥氮平、喹硫平、氯丙嗪、舒必利治疗后出现高泌乳素血症的,按随机数字表法平均分成3组,每组为100例患者,分别合并不同剂量(5 mg/d,10 mg/d,15 mg/d)的阿立哌唑进行干预,持续8周,检测3组患者治疗前和治疗第4周末、8周末血浆泌乳素水平,以阳性和阴性症状量表(PANSS)和(TESS)评定治疗前和治疗第4周末、第8周末的疗效及安全性.结果 (1)3组在合并阿立哌唑治疗第4、8周末泌乳素水平均较治疗前明显下降,每组差异均有统计学意义(P<0.05),但组间差异却无统计学意义(P>0.05);(2)3组PANSS总分在治疗第4、8周末均较治疗前均有明显下降,差异有统计学意义(P<0.05),但3组间差异无统计学意义(P>0.05);(3)合并阿立哌唑15mg/d组不良反应在治疗第4、8周末明显高于合并阿立哌唑5 mg/d组及10 mg/d组,差异有统计学意义(P<0.05),而10 mg/d和5 mg/d组之间不良反应在治疗第4、8周末差异无统计学意义(P>0.05).结论 (1)合并阿立哌唑治疗可以有效降低抗精神病药物所致高泌乳素血症;(2)对抗精神病药物所致高泌乳素血症女性患者合并5~l0 mg/d阿立哌唑更为安全有效.Objective To observe the efficacy and safety of different doses of aripirazole on antipsychoticsinduced hyperprolactinemia with first-episode schizophrenia females. Methods 300 first- episode schizophreniafemales with antipsychotics（risperidone, olanzapine, quetiapine, chlorpromazine and sulpiride ） inducedhyperprolactinemia were randomly divided into three groups, each group had 100 patients. Different doses（5md/d,10 mg/d,15 mg/d） aripiprazole was administered to the patients in the three groups for 8 weeks. The PRLwas measured before treatment and the end of 4 th week,8 hweek after the combination with aripiprazole. Allpatients were assessed with Positive and Negative Symptoms Rating Scale（PANSS） and Treatment EmergentSymptom Scale（TESS） to evaluate the curative effect and safety before treatment and at the end of 4th week,8thweek. Results（1） The PRL at the end of 4th,8th week after combination treatment at the three groups wassignificantly lower than that of pre treatment （ P〈0.05）, （2） There was significant changes in total score of PANSS at the end of the 4th,8th week compared with the pretreatment （P 〉0.05） . But there was no statisticaldifference between the three groups （ P〉0.05） . （3） At the end of the 4th,8th week,the score of TESS in15mg/d aripiprazole group was significant higher than that in 10mg/d and 5mg/d aripiprazole groups（ P〈0.05 ） .Theadverse reactions between 10mg/d and 5mg/d were not statistically significant in the treatment of the 4th and 8thweekends （ P〉0.05） .Conclusions （ 1） The combination of aripiprazole is effective in reducing hyperprolactincaused by antipsychotics. （2） Combination with 5mg-10 mg/d aripiprazole is safer and more effective forhyperprolactin mia caused by antipsychotics.

关 键 词：阿立哌唑 精神分裂症 抗精神病药物 高泌乳素血症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]