血管内皮生长因子和SOX2在肺鳞状细胞癌中的表达及其与预后的关系  

Association of expressions of VEGF and SOX2 in squamous cell lung cancer with prognosis

作　　者：赵璐[1] 宋永波[1] 张艳苓[1] 杜小明[1] 潘旋 

机构地区：[1]皖北煤电集团总医院肿瘤一科,安徽省宿州市234000 [2]江苏省肿瘤医院肿瘤内科,南京市210000

出　　处：《实用医学杂志》2017年第23期3880-3885,共6页The Journal of Practical Medicine

基　　金：国家自然科学基金资助项目(编号:81502678)

摘　　要：目的探讨血管内皮生长因子(VEGF)和SOX2在肺鳞状细胞癌发生转移及预后的作用。方法应用免疫组织化学方法检测47例肺鳞状细胞癌、30例癌旁组织中VEGF及SOX2的表达情况,并用统计学方法分析VEGF和SOX2蛋白的表达与临床参数的关系及其与预后的关系。结果 (1)肺鳞癌中VEGF与SOX2的表达率分别为66.0%及68.1%,癌旁组织中分别是16.2%及8.66%,二者差异均有统计学意义(均P<0.01)。(2)VEGF的高表达与肺鳞癌患者出现淋巴结转移及高临床分期有关(P<0.05),SOX2的高表达与肺鳞癌患者肿瘤分化程度及淋巴结转移有关(P<0.05)。(3)Spearman相关性分析发现,在肺鳞癌中VEGF的表达与SOX2的表达呈正相关关系(r=0.375,P=0.009)。生存分析显示肺鳞癌患者中同时表达VEGF及SOX2与VEGF或SOX2单独表达或不表达相比具有较差的预后(P<0.05)。(4)COX回归分析显示肿瘤大小与淋巴结转移为肺SCLC的独立预后因素。结论肺鳞癌中VEGF的表达与淋巴结转移及高临床分期呈正相关,SOX2的表达与肿瘤分化程度及淋巴结转移呈正相关,VEGF及SOX2的高表达可能提示肺鳞癌患者有着较差的预后。Objective To explore the effects of VEGF and SOX2 on metastasis and prognosis of squamous cell lung carcinoma （SCLC）. Methods Immunohistochemical method was used to detect 47 cases of pulmonary squamous cell carcinoma and 30 cases of para-carcinoma tissue in the expression of VEGF and SOX2. The relation- ship between the expressions of VEGF and SOX2 with the clinical parameters and prognosis were analyzed statisti- cally. Results The positive expression rates of VEGF and SOX2 in the SCLC tissues were higher than adjacent normal tissues. There was a significant correlation between VEGF and SOX2 expressions. VEGF expression was as- sociated with lymph node metastases and TNM stage. SOX2 expression was associated with tumor differentiation and lymph node status. Survival analysis indicated that VEGF （＋）/SOX2 （＋） patients had the worst prognosis, Fur- thermore, multivariate analysis suggested that tumor diameter and lymph node metastases were independent prog- nostic factors for SCLC. Conclusion The expression of VEGF is positively correlated with lymph node metastasis and clinical stage, the expression of SOX2 is positively correlated with tumor differentiation degree and lymph node metastasis, and the high expressions of VEGF and SOX2 may indicate the poor prognosis for lung squamous cancer patients.

关 键 词：肺鳞状细胞癌 血管内皮生长因子 SOX2 预后 

分 类 号：R734.2[医药卫生—肿瘤]